Journal article
Microvascular changes that stagger the mind
The Journal of clinical investigation, Vol.131(18), e153202
09/15/2021
DOI: 10.1172/JCI153202
PMCID: PMC8439589
PMID: 34523619
Abstract
Hypertension is a leading cause of cognitive impairment and dementias. Such loss of brain health has a vascular component, but the mechanisms involved are poorly defined. In this issue of the JCI, Koide et al. provide evidence that end-organ effects of hypertension on capillary endothelium and inward-rectifier K+ channels (Kir2.1) impair integrated propagation of electrical signals and vasodilation upstream, resulting in reduced neurovascular coupling (NVC) despite neural activation. NVC was partly restored by amlodipine, but not losartan. Moreover, NVC was improved by eplerenone in the presence of losartan, suggesting a role for aldosterone. These findings support the concept that endothelial cells and Kir2.1 are potential therapeutic targets to prevent or reverse the loss of NVC and the vascular component of cognitive deficits that occur with increased frequency during hypertension.
Details
- Title: Subtitle
- Microvascular changes that stagger the mind
- Creators
- Frank M. Faraci - Univ Iowa, Carver Coll Med, Dept Internal Med, Francois M Abboud Cardiovasc Ctr, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.131(18), e153202
- Publisher
- Amer Soc Clinical Investigation Inc
- DOI
- 10.1172/JCI153202
- PMID
- 34523619
- PMCID
- PMC8439589
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Number of pages
- 4
- Grant note
- NS-096465; NS-108409 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 09/15/2021
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984303745202771
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