Journal article
Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer
Cancer letters, Vol.331(1), pp.99-104
04/30/2013
DOI: 10.1016/j.canlet.2012.12.016
Abstract
We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was elevated in tumors with p53 null mutations compared to p53 missense mutation or no mutation. Disease recurrence was increased with higher MVD in both unadjusted and adjusted analyses. In adjusted analysis, p53 null mutation was associated with increased recurrence and worse overall survival. Worse overall survival and increased recurrence risk were also associated with the combination of CD31 MVD values >25 vessels/HPF and any p53 mutation. P53 mutation status and MVD may have prognostic significance in patients with advanced-stage ovarian cancer. Tumors with p53 null mutations are likely to be more vascular, contributing to decreased survival and increased recurrence probability.
Details
- Title: Subtitle
- Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer
- Creators
- Niyati J. NadkarniKoen De Geest - University of IowaTraci NeffBarry De YoungDavid P. Bender - University of IowaAmina AhmedBrian J Smith - University of Iowa, BiostatisticsAnna ButtonMichael J. Goodheart - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Cancer letters, Vol.331(1), pp.99-104
- DOI
- 10.1016/j.canlet.2012.12.016
- ISSN
- 0304-3835
- Language
- English
- Date published
- 04/30/2013
- Academic Unit
- Internal Medicine; Obstetrics and Gynecology
- Record Identifier
- 9983557110702771
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