Journal article
Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease
Neuropsychologia, Vol.117, pp.113-122
08/2018
DOI: 10.1016/j.neuropsychologia.2018.05.020
PMCID: PMC6524769
PMID: 29802866
Abstract
Mid-frontal theta activity underlies cognitive control. These 4–8 Hz rhythms are modulated by cortical dopamine and can be abnormal in patients with Parkinson's disease (PD). Here, we investigated mid-frontal theta deficits in PD patients during a task explicitly involving cognitive control. We collected scalp EEG from high-performing PD patients and demographically matched controls during performance of a modified Simon reaction-time task. This task involves cognitive control to adjudicate response conflict and error-related adjustments. Task performance of PD patients was indistinguishable from controls, but PD patients had less mid-frontal theta modulations around cues and responses. Critically, PD patients had attenuated mid-frontal theta activity specifically associated with response conflict and post-error processing. These signals were unaffected by medication or motor scores. Post-error mid-frontal theta activity was correlated with disease duration. Classification of control vs. PD from these data resulted in a specificity of 69% and a sensitivity of 72%. These findings help define the scope of mid-frontal theta aberrations during cognitive control in PD, and may provide insight into the nature of PD-related cognitive dysfunction.\n•Cognitive control involves mid-frontal theta activity.•We investigated mid-frontal theta in PD patients using a task that explicitly measures cognitive control.•Mid-frontal theta activity related to conflict and error-related cognitive control is attenuated in PD.•These data help define the scope of cognitive deficits in PD.
Details
- Title: Subtitle
- Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease
- Creators
- Arun Singh - Department of Neurology, University of Iowa, Iowa City, IA, United StatesSarah Pirio Richardson - Department of Neurology, University of New Mexico Health Sciences Center, United StatesNandakumar Narayanan - Department of Neurology, University of Iowa, Iowa City, IA, United StatesJames F Cavanagh - Department of Psychology, University of New Mexico, United States
- Resource Type
- Journal article
- Publication Details
- Neuropsychologia, Vol.117, pp.113-122
- DOI
- 10.1016/j.neuropsychologia.2018.05.020
- PMID
- 29802866
- PMCID
- PMC6524769
- NLM abbreviation
- Neuropsychologia
- ISSN
- 0028-3932
- eISSN
- 1873-3514
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000065, name: NINDS, award: R01100849; DOI: 10.13039/100000057, name: NIGMS, award: 1P20GM109089-01A1
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984070854302771
Metrics
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