Journal article
Midbrain serotonergic neurons are central pH chemoreceptors
Nature neuroscience, Vol.6(11), pp.1139-1140
11/2003
DOI: 10.1038/nn1130
PMID: 14517544
Abstract
Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO2/pH and are closely associated with large penetrating arteries. We propose that midbrain raphé neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.
Details
- Title: Subtitle
- Midbrain serotonergic neurons are central pH chemoreceptors
- Creators
- Wengang Wang - Department of Neurology, 333 Cedar Street, Yale UniversityChristopher A Severson - Department of Neurology, 333 Cedar Street, Yale UniversityVincent A Pieribone - Departments of Cellular & Molecular Physiology, 333 Cedar Street, Yale University The John B L Pierce LaboratoryGeorge B Richerson - Department of Neurology, 333 Cedar Street, Yale University Departments of Cellular & Molecular Physiology, 333 Cedar Street, Yale University The Veteran's Affairs Medical CenterCarolin I Dohle - Department of Neurophysiology, Universitätsstrasse 150, Ruhr-Universität
- Resource Type
- Journal article
- Publication Details
- Nature neuroscience, Vol.6(11), pp.1139-1140
- DOI
- 10.1038/nn1130
- PMID
- 14517544
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- Language
- English
- Date published
- 11/2003
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020602802771
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