Middle East respiratory syndrome and severe acute respiratory syndrome

Rahul Vijay; Stanley Perlman

doi:10.1016/j.coviro.2016.01.011

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Middle East respiratory syndrome and severe acute respiratory syndrome

Journal article

Open access

Peer reviewed

Middle East respiratory syndrome and severe acute respiratory syndrome

Rahul Vijay and Stanley Perlman

Current opinion in virology, Vol.16, pp.70-76

02/2016

DOI: 10.1016/j.coviro.2016.01.011

PMCID: PMC4821769

PMID: 26855039

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Abstract

The recent emergence of the Middle East respiratory syndrome (MERS)-CoV, a close relative of the Severe Acute respiratory syndrome (SARS)-CoV, both of which caused a lethal respiratory infection in humans, reinforces the need for further understanding of coronavirus pathogenesis and the host immune response. These viruses have evolved diverse strategies to evade and block host immune responses, facilitating infection and transmission. Pathogenesis following infection with these viruses is characterized by a marked delay in the induction of Type I interferon (IFN I) and, subsequently, by a poor adaptive immune response. Therapies that expedite IFN I induction as well as interventions that antagonize immunoevasive virus proteins are thus promising candidates for immune modulation.

T-Lymphocyte Subsets - immunology

Disease Susceptibility

Severe Acute Respiratory Syndrome - virology

Immunomodulation

Humans

Severe Acute Respiratory Syndrome - immunology

Coronavirus Infections - immunology

Host-Pathogen Interactions - immunology

Coronavirus Infections - transmission

Epitopes - immunology

Animals

Coronavirus Infections - metabolism

Coronavirus Infections - virology

T-Lymphocyte Subsets - metabolism

Severe Acute Respiratory Syndrome - metabolism

Middle East Respiratory Syndrome Coronavirus - physiology

Details

Title: Subtitle: Middle East respiratory syndrome and severe acute respiratory syndrome
Creators: Rahul Vijay - Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, United States
Stanley Perlman - Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, United States; Department of Microbiology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: Stanley-perlman@uiowa.edu
Resource Type: Journal article
Publication Details: Current opinion in virology, Vol.16, pp.70-76
DOI: 10.1016/j.coviro.2016.01.011
PMID: 26855039
PMCID: PMC4821769
NLM abbreviation: Curr Opin Virol
ISSN: 1879-6257
eISSN: 1879-6265
Publisher: Netherlands
Grant note: P01 AI060699 / NIAID NIH HHS R01 AI091322 / NIAID NIH HHS
Language: English
Date published: 02/2016
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777352702771

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