Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors

William Sedley; Sukhbinder Kumar; Siobhan Jones; Andrew Levy; Karl Friston; Tim Griffiths; Paul Goldsmith

doi:10.1016/j.neubiorev.2024.105536

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Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors

Journal article

Open access

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Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors

William Sedley, Sukhbinder Kumar, Siobhan Jones, Andrew Levy, Karl Friston, Tim Griffiths and Paul Goldsmith

Neuroscience and biobehavioral reviews, Vol.157, 105536

01/06/2024

DOI: 10.1016/j.neubiorev.2024.105536

PMID: 38185265

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Abstract

Until now, a satisfying account of the cause and purpose of migraine has remained elusive. We explain migraine within the frameworks of allostasis (the situationally-flexible, forward-looking equivalent of homeostasis) and active inference (interacting with the environment via internally-generated predictions). Due to its multimodality, and long timescales between cause and effect, allostasis is inherently prone to catastrophic error, which might be impossible to correct once fully manifest, an early indicator which is elevated prediction error (discrepancy between prediction and sensory input) associated with internal sensations (interoception). Errors can usually be resolved in a targeted manner by action (correcting the physiological state) or perception (updating predictions in light of sensory input); persistent errors are amplified broadly and multimodally, to prioritise their resolution (the migraine premonitory phase); finally, if still unresolved, progressive amplification renders further changes to internal or external sensory inputs intolerably intense, enforcing physiological stability, and facilitating accurate allostatic prediction updating. As such, migraine is an effective 'failsafe' for allostasis, however it has potential to become excessively triggered, therefore maladaptive.

Homeostasis

Interoception

Active inference

Migraine

Allostasis

Details

Title: Subtitle: Migraine as an allostatic reset triggered by unresolved interoceptive prediction errors
Creators: William Sedley - Newcastle University
Sukhbinder Kumar - University of Iowa
Siobhan Jones - Newcastle University
Andrew Levy - Wellcome Centre for Human Neuroimaging
Karl Friston - Wellcome Centre for Human Neuroimaging
Tim Griffiths - Newcastle University
Paul Goldsmith - Imperial College London
Resource Type: Journal article
Publication Details: Neuroscience and biobehavioral reviews, Vol.157, 105536
DOI: 10.1016/j.neubiorev.2024.105536
PMID: 38185265
NLM abbreviation: Neurosci Biobehav Rev
ISSN: 0149-7634
eISSN: 1873-7528
Grant note: DOI: 10.13039/100010269, name: Wellcome Trust; DOI: 10.13039/501100000272, name: National Institute for Health and Care Research
Language: English
Date published: 01/06/2024
Academic Unit: Psychological and Brain Sciences; Neurosurgery
Record Identifier: 9984544954002771

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