Migration of Cells With Immunoglobulin/c-myc Recombinations in Lymphoid Tissues of Mice

Jürgen R Müller; Gary M Jones; Siegfried Janz; Michael Potter

doi:10.1182/blood.V89.1.291

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Migration of Cells With Immunoglobulin/c-myc Recombinations in Lymphoid Tissues of Mice

Journal article

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Peer reviewed

Migration of Cells With Immunoglobulin/c-myc Recombinations in Lymphoid Tissues of Mice

Jürgen R Müller, Gary M Jones, Siegfried Janz and Michael Potter

Blood, Vol.89(1), pp.291-296

01/01/1997

DOI: 10.1182/blood.V89.1.291

PMID: 8978304

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Abstract

Abstract Recombinations between c-myc and immunoglobulin (Ig) sequences that typically occur in pristane-induced mouse plasmacytomas were detected in secondary lymphoid tissues from normal mice, chiefly in the gut-associated lymphoid tissue. Based on the analysis of recombination sequences as clonotypic markers, migration of c-myc recombination-positive cells was observed between Peyer's patches and into the intestine. Treatment of plasmacytoma-susceptible BALB/cAn mice with pristane induced proliferation and migration of these cells into mesenteric lymph node, spleen, and oil granuloma within 7 days. Plasmacytoma-resistant strains of mice (DBA/2N, C3H/HeJ, C57BL/6) differed in that (1) they harbored fewer clones (Ig/c-myc recombinations were detected in 33% of resistant mice versus 91% of BALB/cAn mice after pristane treatment); (2) Ig/c-myc-positive cells were rarely detected in the oil granuloma, and (3) c-myc recombined predominantly with the Ig α locus in BALB/cAn mice (72%), but with the Igμ locus in DBA/2N and in C57BL/6 (67%). The results demonstrate that normal mice generate a large number of lymphocytes with aberrant c-myc in intestinal tissues without developing tumors.

Details

Title: Subtitle: Migration of Cells With Immunoglobulin/c-myc Recombinations in Lymphoid Tissues of Mice
Creators: Jürgen R Müller - From the Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD
Gary M Jones - From the Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD
Siegfried Janz - From the Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD
Michael Potter - From the Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD
Resource Type: Journal article
Publication Details: Blood, Vol.89(1), pp.291-296
DOI: 10.1182/blood.V89.1.291
PMID: 8978304
NLM abbreviation: Blood
ISSN: 0006-4971
eISSN: 1528-0020
Language: English
Date published: 01/01/1997
Academic Unit: Pathology
Record Identifier: 9984083811102771

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