Journal article
Mild Cognitive Impairment and 10-Year Trajectories of Disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly Cohort
Journal of the American Geriatrics Society (JAGS), Vol.53(11), pp.1966-1972
11/2005
DOI: 10.1111/j.1532-5415.2005.53566.x
PMID: 16274380
Abstract
OBJECTIVES: To apply diagnostic criteria for mild cognitive impairment (MCI) to a geographically representative sample, to estimate the prevalence of MCI, and to estimate 10-year trajectories of incident disability for cognitively intact participants and subgroups with MCI. DESIGN: Prospective cohort; 10 years of follow-up. SETTING: Community-based survey of noninstitutionalized population aged 65 and or older in two rural Iowa counties (Washington and Iowa). PARTICIPANTS: Iowa Established Populations for Epidemiologic Studies of the Elderly (aged ≥65; N = 3,673; 61.3% female; 99.9% white). MEASUREMENTS: Age, sex, education, Short Portable Mental Status Questionnaire (SPMSQ), 20-item word recall, activities of daily living (ADLs), instrumental activities of daily living (IADLs), chronic medical conditions. RESULTS: MCI was prevalent in 24.7% of participants at baseline. Most participants in the overall cohort remained stable or changed slowly (≤1 new limitations) over 10 years (63.1% for SPMSQ, 89.3% for word recall, and 61.7% for ADL disability). For MCI/no prevalent IADL disability (Stage 1 MCI), disability progression was similar to that in the cognitively intact subgroup (median = 0.08 vs 0.05 disabilities per year). For MCI plus prevalent IADL disability (Stage 2 MCI), the median rate of change was equivalent to that of the severely impaired (0.23 disabilities per year; interquartile range = 0.12-0.36). CONCLUSION: Unlike participants with MCI who reported no IADL limitations, those with such limitations were more likely to develop ADL disability - a prerequisite for a diagnosis of dementia. © 2005 by the American Geriatrics Society.
Details
- Title: Subtitle
- Mild Cognitive Impairment and 10-Year Trajectories of Disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly Cohort
- Creators
- Jama L. Purser - Duke UniversityGerda G. Fillenbaum - Duke UniversityCarl F. Pieper - Duke UniversityRobert B. Wallace - Duke University
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.53(11), pp.1966-1972
- DOI
- 10.1111/j.1532-5415.2005.53566.x
- PMID
- 16274380
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Publisher
- Blackwell Science Inc
- Number of pages
- 7
- Language
- English
- Date published
- 11/2005
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363616902771
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