Journal article
Mild hyperthermia as a potential mechanism to locally enhance cell growth kinetics
Journal of drug targeting, Vol.17(9), pp.719-723
11/2009
DOI: 10.3109/10611860903074968
PMID: 19845488
Abstract
The effect of mild hyperthermia on growth kinetics of two human glioma and one mouse fibroblast cell line was evaluated over a 12 h (short-term) or 7 day (long-term) period. All cell lines showed growth enhancement at 38°C, although the effect in C3H 10T mouse fibroblasts was more pronounced and had a more rapid onset than in U87MG or LN71 glioma cells. At 39°C, growth of C3H 10T cells was slightly reduced and glioma cell lines similar to that of their respective 37°C controls. At 40°C, C3H 10T cells showed a more rapid and dramatic growth reduction than glioma cell lines and accumulated in both G0/G1 and G2 checkpoint compartments. In contrast, U87MG cells accumulated only in G2 and LN71 showed no checkpoint accumulation. The findings indicate that cell lines are differentially responsive to small temperature elevations. If similar differences exist between normal and diseased human tissues, local application of mild hyperthermia might offer a noninvasive and cost-effective method to achieve local enhancement of drugs that target proliferating tissue.
Details
- Title: Subtitle
- Mild hyperthermia as a potential mechanism to locally enhance cell growth kinetics
- Creators
- Joseph J Morrissey - 1College of Pharmacy, Nova Southeastern University, Ft. Lauderdale, FL, USARyuji Higashikubo - 2Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USAPrabhat C Goswami - 3Free Radical & Radiation Biology Program, University of Iowa, Iowa City, IA, USAPhilip Dixon - 4Department of Statistics, Iowa State University, Ames, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of drug targeting, Vol.17(9), pp.719-723
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10611860903074968
- PMID
- 19845488
- ISSN
- 1061-186X
- eISSN
- 1029-2330
- Language
- English
- Date published
- 11/2009
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047747202771
Metrics
22 Record Views