Journal article
Mild intraoperative hypothermia during surgery for intracranial aneurysm
The New England journal of medicine, Vol.352(2), pp.135-145
01/13/2005
DOI: 10.1056/NEJMoa040975
PMID: 15647576
Abstract
Surgery for intracranial aneurysm often results in postoperative neurologic deficits. We conducted a randomized trial at 30 centers to determine whether intraoperative cooling during open craniotomy would improve the outcome among patients with acute aneurysmal subarachnoid hemorrhage.
A total of 1001 patients with a preoperative World Federation of Neurological Surgeons score of I, II, or III ("good-grade patients"), who had had a subarachnoid hemorrhage no more than 14 days before planned surgical aneurysm clipping, were randomly assigned to intraoperative hypothermia (target temperature, 33 degrees C, with the use of surface cooling techniques) or normothermia (target temperature, 36.5 degrees C). Patients were followed closely postoperatively and examined approximately 90 days after surgery, at which time a Glasgow Outcome Score was assigned.
There were no significant differences between the group assigned to intraoperative hypothermia and the group assigned to normothermia in the duration of stay in the intensive care unit, the total length of hospitalization, the rates of death at follow-up (6 percent in both groups), or the destination at discharge (home or another hospital, among surviving patients). At the final follow-up, 329 of 499 patients in the hypothermia group had a Glasgow Outcome Score of 1 (good outcome), as compared with 314 of 501 patients in the normothermia group (66 percent vs. 63 percent; odds ratio, 1.14; 95 percent confidence interval, 0.88 to 1.48; P=0.32). Postoperative bacteremia was more common in the hypothermia group than in the normothermia group (5 percent vs. 3 percent, P=0.05).
Intraoperative hypothermia did not improve the neurologic outcome after craniotomy among good-grade patients with aneurysmal subarachnoid hemorrhage.
Details
- Title: Subtitle
- Mild intraoperative hypothermia during surgery for intracranial aneurysm
- Creators
- Michael M Todd - Department of Anesthesia, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City 52242, USA. michael-todd@uiowa.eduBradley J HindmanWilliam R ClarkeJames C TornerIntraoperative Hypothermia for Aneurysm Surgery Trial (IHAST) Investigators
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.352(2), pp.135-145
- DOI
- 10.1056/NEJMoa040975
- PMID
- 15647576
- NLM abbreviation
- N Engl J Med
- ISSN
- 1533-4406
- eISSN
- 1533-4406
- Publisher
- United States
- Grant note
- R01 NS38554 / NINDS NIH HHS
- Language
- English
- Date published
- 01/13/2005
- Academic Unit
- Epidemiology; Surgery; Anesthesia; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984002487202771
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