Minimal Fibrinolysis After Acute Intracerebral Hemorrhage Undercuts the Mechanism of Tranexamic Acid

Juliana Silva Pinheiro do Nascimento; Kaleigh Copenhaver; Rajeev Garg; Fernando Goldenberg; Tiffany Chang; Harish Shownkeen; Brett Faine; Paul F Lindholm; James Grotta; Andrew M Naidech

doi:10.1161/JAHA.125.049124

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Minimal Fibrinolysis After Acute Intracerebral Hemorrhage Undercuts the Mechanism of Tranexamic Acid

Journal article

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Peer reviewed

Minimal Fibrinolysis After Acute Intracerebral Hemorrhage Undercuts the Mechanism of Tranexamic Acid

Juliana Silva Pinheiro do Nascimento, Kaleigh Copenhaver, Rajeev Garg, Fernando Goldenberg, Tiffany Chang, Harish Shownkeen, Brett Faine, Paul F Lindholm, James Grotta and Andrew M Naidech

Journal of the American Heart Association, Vol.15(12), e049124

06/16/2026

DOI: 10.1161/JAHA.125.049124

PMID: 42261975

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Abstract

no abstract

fibrinolysis

intracerebral hemorrhage

coagulation

thromboelastography

tranexamic acid

hematoma expansion

Details

Title: Subtitle: Minimal Fibrinolysis After Acute Intracerebral Hemorrhage Undercuts the Mechanism of Tranexamic Acid
Creators: Juliana Silva Pinheiro do Nascimento - Northwestern University
Kaleigh Copenhaver - Northwestern University
Rajeev Garg - Rush University Medical Center
Fernando Goldenberg - University of Chicago
Tiffany Chang - The University of Texas Health Science Center at Houston
Harish Shownkeen - Northwestern Medicine
Brett Faine - University of Iowa
Paul F Lindholm - Northwestern University
James Grotta - Memorial Hermann
Andrew M Naidech - Northwestern University
Resource Type: Journal article
Publication Details: Journal of the American Heart Association, Vol.15(12), e049124
DOI: 10.1161/JAHA.125.049124
PMID: 42261975
NLM abbreviation: J Am Heart Assoc
ISSN: 2047-9980
eISSN: 2047-9980
Publisher: American Heart Association
Grant note: National Institute of Neurological Disorders and Stroke: R01NS110779
This work was supported by the National Institute of Neurological Disorders and Stroke (R01NS110779).
Language: English
Electronic publication date: 06/09/2026
Date published: 06/16/2026
Academic Unit: Emergency Medicine; Pharmacy Practice and Science
Record Identifier: 9985174611902771

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