Journal article
Minimally differentiated acute leukemia
Leukemia research, Vol.17(3), pp.199-208
1993
DOI: 10.1016/0145-2126(93)90002-3
PMID: 8450670
Abstract
We have studied 35 adult patients with morphologically undifferentiated peroxidase-negative acute leukemia that failed to meet the criteria for acute lymphoblastic leukemia and compared them to patients with FAB M1–M7 seen by the same physicians. The diagnosis of minimally differentiated acute leukemia (MD-AL) was associated with a higher incidence of prior hematologic disease, lower WBC, fewer blood blasts, lower marrow cellularity and a tendency towards older age. Of all patients treated with AML since January 1983, those with MD-AL were less likely to get a complete remission than those with other subtypes (35 vs 64%, p = 0.03). Treatment failure was usually due to resistant disease. Analysis of outcome as a function of drugs used during induction therapy showed an advantage for regimens containing vincristine and prednisone. The leukemic blast cells of nine patients were immunophenotyped for myeloid, lymphoid and megakaryoblast/platelet antigens. Although there were too few for a full statistical analysis as was applied to the larger group of 35 patients with MD-AL, these patients had a lower bone marrow cellularity as compared to FAB M1–M7 and a low remission rate. Eight of these were found to have positive myeloid markers and met the criteria for FAB M0. We conclude that patients with MD-AL form a distinct group with characteristic presenting features and a low response rate. Outcome data suggest that vincristine and prednisone should be included in experimental induction programs.
Details
- Title: Subtitle
- Minimally differentiated acute leukemia
- Creators
- Frank J Cadwell - Department of Medicine, The University of Iowa College of Medicine, Iowa City, IA 52242, U.S.AC.Patrick Burns - Department of Medicine, The University of Iowa College of Medicine, Iowa City, IA 52242, U.S.AFred R Dick - Department of Pathology, The University of Iowa College of Medicine, Iowa City, IA 52242, U.S.AMichael P Jones - Department of Preventive Medicine and Environmental Health (Biostatistics), The University of Iowa College of Medicine, Iowa City, IA 52242, U.S.AKevin D Heckman - Department of Medicine, The University of Iowa College of Medicine, Iowa City, IA 52242, U.S.AGeorge J Weiner - Department of Medicine, The University of Iowa College of Medicine, Iowa City, IA 52242, U.S.AJames A Goeken - Department of Pathology, The University of Iowa College of Medicine, Iowa City, IA 52242, U.S.A
- Resource Type
- Journal article
- Publication Details
- Leukemia research, Vol.17(3), pp.199-208
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0145-2126(93)90002-3
- PMID
- 8450670
- ISSN
- 0145-2126
- eISSN
- 1873-5835
- Language
- English
- Date published
- 1993
- Academic Unit
- Statistics and Actuarial Science; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Public Policy Center (Archive); Internal Medicine
- Record Identifier
- 9983985917302771
Metrics
21 Record Views