Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements

Alexander B Rabovsky; Andrei M Komarov; Jeremy S Ivie; Garry R Buettner

doi:10.1186/1475-2891-9-61

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Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements

Journal article

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Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements

Alexander B Rabovsky, Andrei M Komarov, Jeremy S Ivie and Garry R Buettner

Nutrition journal, Vol.9(1), pp.61-61

2010

DOI: 10.1186/1475-2891-9-61

PMCID: PMC3002910

PMID: 21092298

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Abstract

Multivitamin/multimineral complexes are the most common dietary supplements. Unlike minerals in foods that are incorporated in bioorganic structures, minerals in dietary supplements are typically in an inorganic form. These minerals can catalyze the generation of free radicals, thereby oxidizing antioxidants during digestion. Here we examine the ability of a matrix consisting of an amino acid and non-digestible oligosaccharide (AAOS) to blunt metal-catalyzed oxidations. Monitoring of ascorbate radical generated by copper shows that ascorbate is oxidized more slowly with the AAOS matrix than with copper sulfate. Measurement of the rate of oxidation of ascorbic acid and Trolox ® by catalytic metals confirmed the ability of AAOS to slow these oxidations. Similar results were observed with iron-catalyzed formation of hydroxyl radicals. When compared to traditional forms of minerals used in supplements, we conclude that the oxidative loss of antioxidants in solution at physiological pH is much slower when AAOS is present.

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Title: Subtitle: Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements
Creators: Alexander B Rabovsky - Research & Technology Development, Melaleuca Inc. Idaho Falls, ID, 83402, USA
Andrei M Komarov - Department of Biochemistry and Molecular Biology, The George Washington University, Washington D.C. 20037, USA
Jeremy S Ivie - Research & Technology Development, Melaleuca Inc. Idaho Falls, ID, 83402, USA
Garry R Buettner - Free Radical and Radiation Biology, The University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Nutrition journal, Vol.9(1), pp.61-61
DOI: 10.1186/1475-2891-9-61
PMID: 21092298
PMCID: PMC3002910
NLM abbreviation: Nutr J
ISSN: 1475-2891
eISSN: 1475-2891
Publisher: BioMed Central
Language: English
Date published: 2010
Academic Unit: Radiation Oncology
Record Identifier: 9984047712902771

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