Journal article
Minor physical anomalies in familial and sporadic schizophrenia: the Maudsley family study
Journal of neurology, neurosurgery and psychiatry, Vol.64(1), pp.56-60
01/01/1998
DOI: 10.1136/jnnp.64.1.56
PMCID: PMC2169911
PMID: 9436728
Abstract
OBJECTIVES
—(1) To test the hypothesis that minor
physical anomalies are increased in patients with schizophrenia and (2)
to investigate differences in the prevalence of minor physical
anomalies in patients with familial and sporadic schizophrenia and
their first degree relatives.
METHODS
—A weighted Waldrop assessment was carried
out on 214 subjects in five groups: schizophrenic patients from
multiply affected families; first degree relatives of these familial
schizophrenic patients; sporadic schizophrenic patients; first degree
relatives of these sporadic schizophrenic patients, and normal
controls. Broad and narrow criteria for abnormality were defined based
on the distribution of minor physical anomalies in the control group.
RESULTS
—(1) The total schizophrenic group did not
have a significant increase in minor physical anomalies using a narrow
criterion of abnormality, but did when a broader criterion was used.
(2) A significant increase in the proportion of subjects with an
abnormally high number of minor physical abnormalities was shown in the
group of sporadic schizophrenic patients (uncorrected p<0.01).
Separate analyses for males and females showed a significant increase
in the male sporadic group (uncorrected p<0.05), and a smaller
non-significant increase in the female sporadic group. Neither the
familial schizophrenic group nor either group of first degree relatives
showed any significant increases in the proportion of patients with
high abnormality scores.
CONCLUSION
—This work supports prenatal
developmental abnormality as a mechanism for sporadic, but not
familial, schizophrenia.
Details
- Title: Subtitle
- Minor physical anomalies in familial and sporadic schizophrenia: the Maudsley family study
- Creators
- T Griffiths - Newcastle UniversityT Sigmundsson - University of Newcastle AustraliaN Takei - Newcastle UniversityS Frangou - Newcastle UniversityP Birkett - Newcastle UniversityT Sharma - University of Newcastle AustraliaA Reveley - Newcastle UniversityR Murray - Newcastle University
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, neurosurgery and psychiatry, Vol.64(1), pp.56-60
- DOI
- 10.1136/jnnp.64.1.56
- PMID
- 9436728
- PMCID
- PMC2169911
- NLM abbreviation
- J Neurol Neurosurg Psychiatry
- ISSN
- 0022-3050
- eISSN
- 1468-330X
- Publisher
- BMJ Group
- Language
- English
- Date published
- 01/01/1998
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984627313002771
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