Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function

Ronald A Merrill; Stefan Strack

doi:10.1016/j.biocel.2013.12.012

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Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function

Journal article

Peer reviewed

Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function

Ronald A Merrill and Stefan Strack

The international journal of biochemistry & cell biology, Vol.48(1), pp.92-96

03/2014

DOI: 10.1016/j.biocel.2013.12.012

PMCID: PMC3940257

PMID: 24412345

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Abstract

Mitochondria are best known for their role as cellular power plants, but they also serve as signaling hubs, regulating cellular proliferation, differentiation, and survival. A kinase anchoring protein 1 (AKAP1) is a scaffold protein that recruits protein kinase A (PKA) and other signaling proteins, as well as RNA, to the outer mitochondrial membrane. AKAP1 thereby integrates several second messenger cascades to modulate mitochondrial function and associated physiological and pathophysiological outcomes. Here, we review what is currently known about AKAP1's macromolecular interactions in health and disease states, including obesity. We also discuss dynamin-related protein 1 (Drp1), the enzyme that catalyzes mitochondrial fission, as one of the key substrates of the PKA/AKAP1 signaling complex in neurons. Recent evidence suggests that AKAP1 has critical roles in neuronal development and survival, which are mediated by inhibitory phosphorylation of Drp1 and maintenance of mitochondrial integrity.

Mitochondrial Dynamics

Phosphorylation

Animals

Signal Transduction

Humans

Mitochondria - metabolism

A Kinase Anchor Proteins - metabolism

Details

Title: Subtitle: Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function
Creators: Ronald A Merrill - Department of Pharmacology, University of Iowa, Iowa City, USA
Stefan Strack - Department of Pharmacology, University of Iowa, Iowa City, USA. Electronic address: stefan-strack@uiowa.edu
Resource Type: Journal article
Publication Details: The international journal of biochemistry & cell biology, Vol.48(1), pp.92-96
DOI: 10.1016/j.biocel.2013.12.012
PMID: 24412345
PMCID: PMC3940257
NLM abbreviation: Int J Biochem Cell Biol
ISSN: 1357-2725
eISSN: 1878-5875
Publisher: Netherlands
Grant note: NS057714 / NINDS NIH HHS R56 NS056244 / NINDS NIH HHS R01 NS057714 / NINDS NIH HHS R01 NS056244 / NINDS NIH HHS NS056244 / NINDS NIH HHS
Language: English
Date published: 03/2014
Academic Unit: Pathology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984040493702771

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