Journal article
Mitochondria and Cardiovascular Aging
Circulation research, Vol.110(8), pp.1109-1124
04/13/2012
DOI: 10.1161/CIRCRESAHA.111.246140
PMCID: PMC3867977
PMID: 22499901
Abstract
Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in experimental animal models have indicated the central role of mitochondria both in lifespan determination and cardiovascular aging. In this article we review the evidence supporting the role of mitochondrial oxidative stress, mitochondrial damage and biogenesis as well as the crosstalk between mitochondria and cellular signaling in cardiac and vascular aging. Intrinsic cardiac aging in the murine model closely recapitulates age-related cardiac changes in humans (left ventricular hypertrophy, fibrosis and diastolic dysfunction), while the phenotype of vascular aging include endothelial dysfunction, reduced vascular elasticity and chronic vascular inflammation. Both cardiac and vascular aging involve neurohormonal signaling (e.g. renin-angiotensin, adrenergic, insulin-IGF1 signaling) and cell-autonomous mechanisms. The potential therapeutic strategies to improve mitochondrial function in aging and cardiovascular diseases are also discussed, with a focus on mitochondrial-targeted antioxidants, calorie restriction, calorie restriction mimetics and exercise training.
Details
- Title: Subtitle
- Mitochondria and Cardiovascular Aging
- Creators
- Dao-Fu Dai - Department of Pathology, University of Washington, 1959 Pacific Ave. NE, Seattle, WA 98195, USAPeter S Rabinovitch - Department of Pathology, University of Washington, 1959 Pacific Ave. NE, Seattle, WA 98195, USAZoltan Ungvari - Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City OK 73104
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.110(8), pp.1109-1124
- DOI
- 10.1161/CIRCRESAHA.111.246140
- PMID
- 22499901
- PMCID
- PMC3867977
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Grant note
- P01 AG001751 || AG / National Institute on Aging : NIA P30 AG013280 || AG / National Institute on Aging : NIA R01 HL101186 || HL / National Heart, Lung, and Blood Institute : NHLBI
- Language
- English
- Date published
- 04/13/2012
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984047985802771
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