Mitochondria in the diabetic heart

Heiko Bugger; E Dale Abel

doi:10.1093/cvr/cvq239

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Journal article

Open access

Peer reviewed

Mitochondria in the diabetic heart

Heiko Bugger and E Dale Abel

Cardiovascular research, Vol.88(2), pp.229-240

11/01/2010

DOI: 10.1093/cvr/cvq239

PMCID: PMC2952534

PMID: 20639213

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Abstract

Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that derangements in cardiac energy metabolism play an important role. In particular, abnormalities in cardiomyocyte mitochondrial energetics appear to contribute substantially to the development of cardiac dysfunction in diabetes. This review will summarize these abnormalities in mitochondrial function and discuss potential underlying mechanisms.

Mitochondria, Heart - metabolism

Heart Diseases - metabolism

Oxidative Stress

Signal Transduction

Calcium - metabolism

Mitochondria, Heart - pathology

Diabetes Complications - metabolism

Humans

Risk Factors

Myocardium - pathology

Diabetes Complications - etiology

Heart Diseases - etiology

Insulin - metabolism

Animals

Energy Metabolism

Mitochondrial Proteins - metabolism

Myocardium - metabolism

Protein Processing, Post-Translational

Diabetes Complications - pathology

Heart Diseases - pathology

Details

Title: Subtitle: Mitochondria in the diabetic heart
Creators: Heiko Bugger - Department of Cardiology, University of Freiburg, Freiburg, Germany
E Dale Abel
Resource Type: Journal article
Publication Details: Cardiovascular research, Vol.88(2), pp.229-240
Publisher: England
DOI: 10.1093/cvr/cvq239
PMID: 20639213
PMCID: PMC2952534
ISSN: 0008-6363
eISSN: 1755-3245
Grant note: UO1HL70525 / NHLBI NIH HHS R01HL73167 / NHLBI NIH HHS UO1 HL087947 / NHLBI NIH HHS R01 HL073167 / NHLBI NIH HHS R01 HL70070 / NHLBI NIH HHS
Language: English
Date published: 11/01/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984025297802771

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