Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease

Luis Miguel García-Peña; E Dale Abel; Renata O Pereira

doi:10.2337/dbi23-0003

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Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease

Journal article

Open access

Peer reviewed

Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease

Luis Miguel García-Peña, E Dale Abel and Renata O Pereira

Diabetes (New York, N.Y.), Vol.73(2), pp.151-161

02/01/2024

DOI: 10.2337/dbi23-0003

PMCID: PMC10796300

PMID: 38241507

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Abstract

Mitochondria undergo repeated cycles of fusion and fission that regulate their size and shape by a process known as mitochondrial dynamics. Numerous studies have revealed the importance of this process in maintaining mitochondrial health and cellular homeostasis, particularly in highly metabolically active tissues such as skeletal muscle and the heart. Here, we review the literature on the relationship between mitochondrial dynamics and the pathophysiology of type 2 diabetes and cardiovascular disease (CVD). Importantly, we emphasize divergent outcomes resulting from downregulating distinct mitochondrial dynamics proteins in various tissues. This review underscores compensatory mechanisms and adaptive pathways that offset potentially detrimental effects, resulting instead in improved metabolic health. Finally, we offer a perspective on potential therapeutic implications of modulating mitochondrial dynamics proteins for treatment of diabetes and CVD.

Details

Title: Subtitle: Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease
Creators: Luis Miguel García-Peña - Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA
E Dale Abel - Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA
Renata O Pereira - Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: Diabetes (New York, N.Y.), Vol.73(2), pp.151-161
DOI: 10.2337/dbi23-0003
PMID: 38241507
PMCID: PMC10796300
NLM abbreviation: Diabetes
eISSN: 1939-327X
Grant note: 1R25GM116686 / NIH HHS DK125405 / NIH HHS
Language: English
Date published: 02/01/2024
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984548299102771

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