Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan

Jane L Buchanan; Eric B Taylor

doi:10.3390/biom10081162

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Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan

Journal article

Open access

Peer reviewed

Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan

Jane L Buchanan and Eric B Taylor

Biomolecules (Basel, Switzerland), Vol.10(8), pp.1-19

08/08/2020

DOI: 10.3390/biom10081162

PMCID: PMC7464753

PMID: 32784379

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Abstract

As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration. Emerging research highlights the importance of the MPC in diverse conditions, such as immune cell activation, cancer cell stemness, and dopamine production in Parkinson's disease models. Whether MPC function ameliorates or contributes to disease is highly specific to tissue and cell type. Cell- and tissue-specific differences in MPC content and activity suggest that MPC function is tightly regulated as a mechanism of metabolic, cellular, and organismal control. Accordingly, recent studies on cancer and diabetes have identified protein-protein interactions, post-translational processes, and transcriptional factors that modulate MPC function. This growing body of literature demonstrates that the MPC and other mitochondrial carriers comprise a versatile and dynamic network undergirding the metabolism of health and disease.

Aging - metabolism

Animals

Diabetes Mellitus - metabolism

Humans

Mitochondrial Membrane Transport Proteins - genetics

Mitochondrial Membrane Transport Proteins - metabolism

Monocarboxylic Acid Transporters - genetics

Monocarboxylic Acid Transporters - metabolism

Neoplasms - metabolism

Neurodegenerative Diseases - metabolism

Pyruvic Acid - metabolism

Details

Title: Subtitle: Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan
Creators: Jane L Buchanan - Roy J. and Lucille A. Carver College of Medicine
Eric B Taylor - Roy J. and Lucille A. Carver College of Medicine
Resource Type: Journal article
Publication Details: Biomolecules (Basel, Switzerland), Vol.10(8), pp.1-19
DOI: 10.3390/biom10081162
PMID: 32784379
PMCID: PMC7464753
NLM abbreviation: Biomolecules
ISSN: 2218-273X
eISSN: 2218-273X
Grant note: R01 DK104998 / NIDDK NIH HHS T32 GM007337 / NIGMS NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 08/08/2020
Academic Unit: Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984297508502771

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