Mitochondrial RNA turnover in the presence of cordycepin

E A Zylber; S Perlman; S Penman

doi:10.1016/0005-2787(71)90716-7

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Journal article

Mitochondrial RNA turnover in the presence of cordycepin

E A Zylber, S Perlman and S Penman

Biochimica et biophysica acta. Nucleic acids and protein synthesis, Vol.240(4), pp.588-593

07/29/1971

DOI: 10.1016/0005-2787(71)90716-7

PMID: 5315931

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Abstract

Cordycepin inhibits mitochondrial specific RNA synthesis. In contrast to the drug's effect on the nucleolus, no short RNA molecules are produced. After inhibition, prelabeled 12-S and 21-S molecules decay with a 3-h half-life. The mitochondrial 4-S RNA appears stable. The kinetics of decay of mitochondrial specific protein synthesis resembles that of mitochondrial RNA.

Electrophoresis

Cell Fractionation

Half-Life

HeLa Cells - metabolism

Tritium

Mitochondria - metabolism

Adenosine - pharmacology

Mitochondria - drug effects

HeLa Cells - drug effects

Proteins - metabolism

Ribosomes - drug effects

Uridine - metabolism

Deoxyadenosines - pharmacology

HeLa Cells - cytology

Kinetics

Dactinomycin - pharmacology

RNA - metabolism

Details

Title: Subtitle: Mitochondrial RNA turnover in the presence of cordycepin
Creators: E A Zylber
S Perlman
S Penman
Resource Type: Journal article
Publication Details: Biochimica et biophysica acta. Nucleic acids and protein synthesis, Vol.240(4), pp.588-593
DOI: 10.1016/0005-2787(71)90716-7
PMID: 5315931
NLM abbreviation: Biochim Biophys Acta
ISSN: 0005-2787
Publisher: Netherlands
Language: English
Date published: 07/29/1971
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9983777353802771

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