Journal article
Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes
Physiology (Bethesda, Md.), Vol.21(4), pp.250-258
08/2006
DOI: 10.1152/physiol.00008.2006
PMID: 16868314
Abstract
Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.
Details
- Title: Subtitle
- Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes
- Creators
- Sihem Boudina - Division of Endocrinology, Metabolism, and Diabetes, and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, UtahE. Dale Abel - Division of Endocrinology, Metabolism, and Diabetes, and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah
- Resource Type
- Journal article
- Publication Details
- Physiology (Bethesda, Md.), Vol.21(4), pp.250-258
- DOI
- 10.1152/physiol.00008.2006
- PMID
- 16868314
- ISSN
- 1548-9213
- eISSN
- 1548-9221
- Language
- English
- Date published
- 08/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024527502771
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