Mitochondrial dynamics in neuronal injury, development and plasticity

Kyle H Flippo; Stefan Strack

doi:10.1242/jcs.171017

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Mitochondrial dynamics in neuronal injury, development and plasticity

Journal article

Open access

Peer reviewed

Mitochondrial dynamics in neuronal injury, development and plasticity

Kyle H Flippo and Stefan Strack

Journal of cell science, Vol.130(4), pp.671-681

02/15/2017

DOI: 10.1242/jcs.171017

PMCID: PMC5339882

PMID: 28154157

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Abstract

Mitochondria fulfill numerous cellular functions including ATP production, Ca buffering, neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis and intermediate metabolism. Mitochondrial dynamics, a collective term for the processes of mitochondrial fission, fusion and transport, governs mitochondrial function and localization within the cell. Correct balance of mitochondrial dynamics is especially important in neurons as mutations in fission and fusion enzymes cause peripheral neuropathies and impaired development of the nervous system in humans. Regulation of mitochondrial dynamics is partly accomplished through post-translational modification of mitochondrial fission and fusion enzymes, in turn influencing mitochondrial bioenergetics and transport. The importance of post-translational regulation is highlighted by numerous neurodegenerative disorders associated with post-translational modification of the mitochondrial fission enzyme Drp1. Not surprisingly, mitochondrial dynamics also play an important physiological role in the development of the nervous system and synaptic plasticity. Here, we highlight recent findings underlying the mechanisms and regulation of mitochondrial dynamics in relation to neurological disease, as well as the development and plasticity of the nervous system.

Mitochondrial Dynamics

Neurons - pathology

Animals

Neurodegenerative Diseases - pathology

Energy Metabolism

Neuronal Plasticity

Humans

Neurons - metabolism

Protein Processing, Post-Translational

Neurodegenerative Diseases - metabolism

Details

Title: Subtitle: Mitochondrial dynamics in neuronal injury, development and plasticity
Creators: Kyle H Flippo - Department of Pharmacology, University of Iowa, Iowa City, USA
Stefan Strack - Department of Pharmacology, University of Iowa, Iowa City, USA Stefan-strack@uiowa.edu
Resource Type: Journal article
Publication Details: Journal of cell science, Vol.130(4), pp.671-681
DOI: 10.1242/jcs.171017
PMID: 28154157
PMCID: PMC5339882
NLM abbreviation: J Cell Sci
ISSN: 0021-9533
eISSN: 1477-9137
Publisher: England
Grant note: R56 NS056244 / NINDS NIH HHS R21 NS087908 / NINDS NIH HHS R01 NS056244 / NINDS NIH HHS
Language: English
Date published: 02/15/2017
Academic Unit: Pathology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984040390702771

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