Mitochondrial dysfunction in neurodegenerative disorders

Madelyn M Klemmensen; Seth H Borrowman; Colin Pearce; Benjamin Pyles; Bharatendu Chandra

doi:10.1016/j.neurot.2023.10.002

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Mitochondrial dysfunction in neurodegenerative disorders

Journal article

Open access

Peer reviewed

Mitochondrial dysfunction in neurodegenerative disorders

Madelyn M Klemmensen, Seth H Borrowman, Colin Pearce, Benjamin Pyles and Bharatendu Chandra

Neurotherapeutics, Vol.21(1), e00292

01/2024

DOI: 10.1016/j.neurot.2023.10.002

PMCID: PMC10903104

PMID: 38241161

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Abstract

Recent advances in understanding the role of mitochondrial dysfunction in neurodegenerative diseases have expanded the opportunities for neurotherapeutics targeting mitochondria to alleviate symptoms and slow disease progression. In this review, we offer a historical account of advances in mitochondrial biology and neurodegenerative disease. Additionally, we summarize current knowledge of the normal physiology of mitochondria and the pathogenesis of mitochondrial dysfunction, the role of mitochondrial dysfunction in neurodegenerative disease, current therapeutics and recent therapeutic advances, as well as future directions for neurotherapeutics targeting mitochondrial function. A focus is placed on reactive oxygen species and their role in the disruption of telomeres and their effects on the epigenome. The effects of mitochondrial dysfunction in the etiology and progression of Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease are discussed in depth. Current clinical trials for mitochondria-targeting neurotherapeutics are discussed.

Aging

Bioenergetics

Mitochondria

Neurodegeneration

Reactive oxygen species (ROS)

Details

Title: Subtitle: Mitochondrial dysfunction in neurodegenerative disorders
Creators: Madelyn M Klemmensen - University of Iowa
Seth H Borrowman - University of Iowa Hospitals and Clinics
Colin Pearce - University of Iowa Hospitals and Clinics
Benjamin Pyles - Aper Funis Research, Union River Innovation Center, Ellsworth, ME 04605, USA
Bharatendu Chandra - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Neurotherapeutics, Vol.21(1), e00292
DOI: 10.1016/j.neurot.2023.10.002
PMID: 38241161
PMCID: PMC10903104
NLM abbreviation: Neurotherapeutics
ISSN: 1878-7479
eISSN: 1878-7479
Publisher: Elsevier
Language: English
Electronic publication date: 12/19/2023
Date published: 01/2024
Academic Unit: Stead Family Department of Pediatrics; Medical Genetics and Genomics; Internal Medicine
Record Identifier: 9984548406502771

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