Mitochondrial oxidative stress and mammalian healthspan

Jonathan Wanagat; Dao-Fu Dai; Peter Rabinovitch

doi:10.1016/j.mad.2010.06.002

Back

Mitochondrial oxidative stress and mammalian healthspan

Journal article

Peer reviewed

Mitochondrial oxidative stress and mammalian healthspan

Jonathan Wanagat, Dao-Fu Dai and Peter Rabinovitch

Mechanisms of ageing and development, Vol.131(7), pp.527-535

2010

DOI: 10.1016/j.mad.2010.06.002

PMCID: PMC2933331

PMID: 20566356

View Online

Abstract

Aging of the American society is leading to a growing need for disease-modifying interventions to treat age-related diseases and enhance healthspan. Mitochondria and mitochondrially generated reactive oxygen species appear to play a central role in these processes and are a likely target for interventions. Conventional, untargeted antioxidants have not demonstrated a clear benefit in human studies. As a result, approaches have been developed to target antioxidants specifically to mitochondria. Studies have employed a wide array of targeted molecules including antioxidant enzymes such as catalase, peroxiredoxin, superoxide dismutases and small molecular compounds which recapitulate the antioxidant activities of these enzymes. Lifespan and healthspan effects differ between interventions suggesting varied roles for specific mitochondrial reactive oxygen species and their impact on usual aging. Consistent findings in myocardial protection across various interventions support a focus on the impact of cardiac aging on healthspan. The advancement of mitochondrially targeted small-molecule antioxidants suggests the prospect of swift translation to human use.

Antioxidants

Drug targeting

Mitochondria

Healthspan

Details

Title: Subtitle: Mitochondrial oxidative stress and mammalian healthspan
Creators: Jonathan Wanagat - Department of Medicine, Division of Geriatrics, UCLA, Los Angeles, CA 90095, United States
Dao-Fu Dai - Department Pathology, University of Washington, Seattle, WA 98195, United States
Peter Rabinovitch - Department Pathology, University of Washington, Seattle, WA 98195, United States
Resource Type: Journal article
Publication Details: Mechanisms of ageing and development, Vol.131(7), pp.527-535
DOI: 10.1016/j.mad.2010.06.002
PMID: 20566356
PMCID: PMC2933331
NLM abbreviation: Mech Ageing Dev
ISSN: 0047-6374
eISSN: 1872-6216
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 2010
Academic Unit: Pathology; Iowa Neuroscience Institute; Radiation Oncology
Record Identifier: 9984047688502771

Metrics

22 Record Views

40 Times Cited - Web of Science