Mitochondrial pyruvate carrier function and cancer metabolism

Adam J Rauckhorst; Eric B Taylor

doi:10.1016/j.gde.2016.05.003

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Mitochondrial pyruvate carrier function and cancer metabolism

Journal article

Peer reviewed

Mitochondrial pyruvate carrier function and cancer metabolism

Adam J Rauckhorst and Eric B Taylor

Current opinion in genetics & development, Vol.38, pp.102-109

06/2016

DOI: 10.1016/j.gde.2016.05.003

PMCID: PMC5017534

PMID: 27269731

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Abstract

Metabolic reprogramming in cancer supports the increased biosynthesis required for unchecked proliferation. Increased glucose utilization is a defining feature of many cancers that is accompanied by altered pyruvate partitioning and mitochondrial metabolism. Cancer cells also require mitochondrial tricarboxylic acid cycle activity and electron transport chain function for biosynthetic competency and proliferation. Recent evidence demonstrates that mitochondrial pyruvate carrier (MPC) function is abnormal in some cancers and that increasing MPC activity may decrease cancer proliferation. Here we examine recent findings on MPC function and cancer metabolism. Special emphasis is placed on the compartmentalization of pyruvate metabolism and the alternative routes of metabolism that maintain the cellular biosynthetic pools required for unrestrained proliferation in cancer.

Neoplasms - metabolism

Mitochondrial Membrane Transport Proteins

Cell Proliferation - genetics

Citric Acid Cycle - genetics

Monocarboxylic Acid Transporters

Mitochondria - genetics

Neoplasms - genetics

Membrane Transport Proteins - genetics

Electron Transport - genetics

Humans

Pyruvic Acid - metabolism

Mitochondria - metabolism

Details

Title: Subtitle: Mitochondrial pyruvate carrier function and cancer metabolism
Creators: Adam J Rauckhorst - Department of Biochemistry, Fraternal Order of the Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Holden Comprehensive Cancer Center, and Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Eric B Taylor - Department of Biochemistry, Fraternal Order of the Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Holden Comprehensive Cancer Center, and Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address: eric-taylor@uiowa.edu
Resource Type: Journal article
Publication Details: Current opinion in genetics & development, Vol.38, pp.102-109
DOI: 10.1016/j.gde.2016.05.003
PMID: 27269731
PMCID: PMC5017534
NLM abbreviation: Curr Opin Genet Dev
ISSN: 0959-437X
eISSN: 1879-0380
Publisher: England
Grant note: R01 DK104998 / NIDDK NIH HHS R00 AR059190 / NIAMS NIH HHS T32 HL007638 / NHLBI NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 06/2016
Academic Unit: Molecular Physiology and Biophysics
Record Identifier: 9984025445202771

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