Journal article
Mitomycin induced pulmonary veno-occlusive disease
Respiratory medicine case reports, Vol.34, p.101437
01/01/2021
DOI: 10.1016/j.rmcr.2021.101437
PMCID: PMC8348923
PMID: 34401312
Abstract
Pulmonary veno-occlusive disease (PVOD) is a rare but devastating cause of pulmonary hypertension (PH) characterized by preferential remodeling of the pulmonary venules.
Mitomycin-C (MMC) is an alkylating agent commonly used in chemotherapy with documented lung toxicity as well as PVOD adverse effect. The incidence of PVOD in patients with anal cancer is much higher than in those with idiopathic PVOD, especially following treatment with MMC. An accurate diagnosis of PVOD can be made based on noninvasive investigations utilizing oxygen parameters, low diffusing capacity for carbon monoxide and characteristic signs on high-resolution computed tomography of the chest. No evidence-based medical therapy exists for PVOD at present and lung transplant remains the preferred definitive therapy for eligible patients. We present a case of autopsy confirmed MMC induced PVOD in a patient with metastatic anal cancer.
Details
- Title: Subtitle
- Mitomycin induced pulmonary veno-occlusive disease
- Creators
- Afua Kunadu - SleepMedJ. Stephen Stalls - East Carolina UniversityHeloise Labuschagne - SleepMedAbdullah Thayyil - East Carolina UniversityRandall Falls - East Carolina UniversityVeeranna Maddipati - SleepMed
- Resource Type
- Journal article
- Publication Details
- Respiratory medicine case reports, Vol.34, p.101437
- DOI
- 10.1016/j.rmcr.2021.101437
- PMID
- 34401312
- PMCID
- PMC8348923
- NLM abbreviation
- Respir Med Case Rep
- ISSN
- 2213-0071
- eISSN
- 2213-0071
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Pathology
- Record Identifier
- 9984845251302771
Metrics
3 Record Views