Journal article
Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions
mBio, Vol.12(5), pp.e0176321-e0176321
10/26/2021
DOI: 10.1128/mBio.01763-21
PMCID: PMC8546538
PMID: 34544277
Abstract
A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.
Details
- Title: Subtitle
- Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions
- Creators
- George A O'Toole - Dartmouth CollegeAurélie Crabbé - Ghent University HospitalRolf Kümmerli - University of Zurichgrid.7400.3, Zurich, SwitzerlandJohn J LiPuma - University of MichiganJennifer M Bomberger - University of PittsburghJane C Davies - Royal Brompton HospitalDominique Limoli - University of IowaVanessa V Phelan - University of Colorado Anschutz Medical CampusJames B Bliska - Dartmouth CollegeWilliam H DePas - University of PittsburghLars E Dietrich - 3F (United States)Thomas H Hampton - Dartmouth CollegeRyan Hunter - University of MinnesotaCezar M Khursigara - University of GuelphAlexa Price-Whelan - 3F (United States)Alix Ashare - Dartmouth CollegeRobert A Cramer - Dartmouth CollegeJoanna B Goldberg - Emory UniversityFreya Harrison - University of WarwickDeborah A Hogan - Dartmouth CollegeMichael A Henson - University of Massachusetts AmherstDean R Madden - Dartmouth CollegeJared R Mayers - Brigham and Women's HospitalCarey Nadell - Dartmouth CollegeDianne Newman - California Institute of TechnologyAlice Prince - 3F (United States)Damian W Rivett - Manchester Metropolitan UniversityJoseph D Schwartzman - Dartmouth CollegeDaniel Schultz - Dartmouth CollegeDonald C Sheppard - McGill UniversityAlan R Smyth - University of NottinghamMelanie A Spero - University of OregonBruce A Stanton - Dartmouth CollegePaul E Turner - Yale UniversityChris van der Gast - Manchester Metropolitan Universitygrid.25627.34, Manchester, United KingdomFiona J Whelan - University of NottinghamRachel Whitaker - University of Illinois Urbana-ChampaignKatrine Whiteson - University of California, Irvine
- Resource Type
- Journal article
- Publication Details
- mBio, Vol.12(5), pp.e0176321-e0176321
- DOI
- 10.1128/mBio.01763-21
- PMID
- 34544277
- PMCID
- PMC8546538
- NLM abbreviation
- mBio
- ISSN
- 2161-2129
- eISSN
- 2150-7511
- Grant note
- MR/R001898/1 / Medical Research Council T32 HL007633 / NHLBI NIH HHS R01 AI127548 / NIAID NIH HHS R01 AI103369 / NIAID NIH HHS R01 HL136919 / NHLBI NIH HHS R01 AI155424 / NIAID NIH HHS P20 GM130454 / NIGMS NIH HHS R35 GM128690 / NIGMS NIH HHS P30 DK117469 / NIDDK NIH HHS R01 HL151385 / NHLBI NIH HHS R01 DK104847 / NIDDK NIH HHS R01 HL152190 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS R01 HL136647 / NHLBI NIH HHS
- Language
- English
- Date published
- 10/26/2021
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297425502771
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