Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test

Jan Gläscher; Ralph Adolphs; Daniel Tranel

doi:10.1038/s41467-018-07912-5

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Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test

Journal article

Open access

Peer reviewed

Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test

Jan Gläscher, Ralph Adolphs and Daniel Tranel

Nature communications, Vol.10(1), pp.20-12

01/03/2019

DOI: 10.1038/s41467-018-07912-5

PMCID: PMC6318292

PMID: 30604744

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https://doi.org/10.1038/s41467-018-07912-5View

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Abstract

The role of the frontal lobes in cognition and behavior has long been enigmatic. Over the past decade, computational models have provided a powerful approach to understanding cognition and decision-making. Here, we used a model-based approach to analyze data from a classical task used to assess frontal lobe function, the Wisconsin Card Sorting Test. We applied computational modeling and voxel-based lesion-symptom mapping in 328 patients with focal lesions, to uncover cognitive processes and neural correlates of test scores. Our results reveal that lesions in the right prefrontal cortex are associated with elevated perseverative errors and reductions in the model parameter of sensitivity to punishment. These findings indicate that the capacity to flexibly switch between task sets requires the detection of contingency changes, which are enabled by a sensitivity to punishment that reduces perseverative errors. We demonstrate the power of model-based approaches in understanding patterns of deficits on classical neuropsychological tasks.

Cognition Disorders - physiopathology

Frontal Lobe - physiopathology

Humans

Middle Aged

Male

Cognition

Young Adult

Cognition Disorders - diagnosis

Models, Biological

Wisconsin Card Sorting Test

Computer Simulation

Aged, 80 and over

Adult

Female

Aged

Details

Title: Subtitle: Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test
Creators: Jan Gläscher - Division of Humanities and Social Sciences, Caltech, M/C 228-77, 1200 E. California Blvd, Pasadena, CA, 91125, USA. glaescher@uke.de
Ralph Adolphs - Division of Biology and Biological Engineering, Caltech, M/C 228-77, 1200 E. California Blvd, Pasadena, CA, 91125, USA
Daniel Tranel - Departments of Neurology and Psychological and Brain Sciences, University of Iowa, 200 Hawkins Dr, 2007 RCP, Iowa City, IA, 52242, USA
Resource Type: Journal article
Publication Details: Nature communications, Vol.10(1), pp.20-12
DOI: 10.1038/s41467-018-07912-5
PMID: 30604744
PMCID: PMC6318292
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Publisher: England
Grant note: P50 MH094258 / NIMH NIH HHS
Language: English
Date published: 01/03/2019
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070545902771

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