Journal article
Modeling and simulation of the effects of cyclic loading on articular cartilage lesion formation
International journal for numerical methods in biomedical engineering, Vol.30(10), pp.927-941
10/2014
DOI: 10.1002/cnm.2636
PMCID: PMC4950512
PMID: 24753483
Abstract
We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al., 2012 for the spread of a lesion formed though a single traumatic event. Our model represents 'implicitly' the effects of loading, meaning through a cyclic sink term in the equations for live cells. Our model forms the basis for in silico studies of cartilage damage relevant to questions in osteoarthritis, for example, that may not be easily answered through in vivo or in vitro studies. Computational results are presented that indicate the impact of differing levels of erythropoietin on articular cartilage lesion abatement.
Details
- Title: Subtitle
- Modeling and simulation of the effects of cyclic loading on articular cartilage lesion formation
- Creators
- Xiayi Wang - University of IowaBruce P AyatiMarc J BrouilleteJason M GrahamPrem S RamakrishnanJames A Martin
- Resource Type
- Journal article
- Publication Details
- International journal for numerical methods in biomedical engineering, Vol.30(10), pp.927-941
- Publisher
- England
- DOI
- 10.1002/cnm.2636
- PMID
- 24753483
- PMCID
- PMC4950512
- ISSN
- 2040-7939
- eISSN
- 2040-7947
- Grant note
- 1 P50 AR055533 / NIAMS NIH HHS P50 AR055533 / NIAMS NIH HHS
- Language
- English
- Date published
- 10/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Mathematics
- Record Identifier
- 9983985714302771
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