Journal article
Modeling human cancer cachexia in colon 26 tumor-bearing adult mice
Journal of cachexia, sarcopenia and muscle, Vol.5(4), pp.321-328
12/01/2014
DOI: 10.1007/s13539-014-0141-2
PMCID: PMC4248405
PMID: 24668658
Abstract
Muscle wasting is a profound side effect of advanced cancer. Cancer-induced cachexia decreases patient quality of life and is associated with poor patient survival. Currently, no clinical therapies exist to treat cancer-induced muscle wasting. Although cancers commonly associated with cachexia occur in older individuals, the standard animal models used to elucidate the causes of cachexia rely on juvenile mice.
In an effort to better model human cancer cachexia, we determined whether cachectic features seen in young mice could be achieved in adult, pre-sarcopenic mice following colon 26 (C-26) tumor cell inoculation.
Both young and adult mice developed similar-sized tumors and progressed to cachexia with similar kinetics, as evidenced by losses in body mass, and adipose and skeletal muscle tissues. Proteolytic signaling, including proteasome and autophagy genes, was also increased in muscles from both young and adult tumor-bearing animals. Furthermore, tumor-associated muscle damage and activation of Pax7 progenitor cells was induced in both young and adult mice.
Although cancer cachexia generally occurs in older individuals, these data suggest that the phenotype and underlying mechanisms can be effectively modeled using the currently accepted protocol in juvenile mice.
Details
- Title: Subtitle
- Modeling human cancer cachexia in colon 26 tumor-bearing adult mice
- Creators
- Erin E. Talbert - The Ohio State UniversityGregory A. Metzger - The Ohio State UniversityWei A. He - The Ohio State UniversityDenis C. Guttridge - The Ohio State University
- Resource Type
- Journal article
- Publication Details
- Journal of cachexia, sarcopenia and muscle, Vol.5(4), pp.321-328
- DOI
- 10.1007/s13539-014-0141-2
- PMID
- 24668658
- PMCID
- PMC4248405
- NLM abbreviation
- J Cachexia Sarcopenia Muscle
- ISSN
- 2190-5991
- eISSN
- 2190-6009
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Ohio State Comprehensive Cancer Center R01CA180057 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01 CA180057 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32 CA106196 / Ohio State Cancer Genetics NIH T32 training grant
- Language
- English
- Date published
- 12/01/2014
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259396102771
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