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Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis
Journal article   Open access   Peer reviewed

Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis

Mohan Kumar, Connor R Wilhelm and Alexander W Boyden
The Journal of immunology (1950), Vol.215(7), vkag163
07/10/2026
DOI: 10.1093/jimmun/vkag163
PMID: 42435354
Appears in  UI Libraries Support Open Access
url
https://doi.org/10.1093/jimmun/vkag163View
Published (Version of record) Open Access

Abstract

Success of B cell depletion therapy in multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system, places B cells and their functions center stage in efforts to fully understand pathogenesis. Historically, MS animal models of experimental autoimmune encephalomyelitis have featured B cell-independent disease driven by CD4 T cells activated against central nervous system myelin protein epitopes and have provided many insights into autoreactive T cell biology in the context of neuroinflammation and demyelination. Meanwhile, B cells' growing significance in MS necessitated the development of B cell-dependent experimental autoimmune encephalomyelitis models, which have allowed for critical exploration into pathogenic B cell functions during immune-mediated demyelinating disease, including cytokine and antibody production, as well as antigen presentation to autoreactive CD4 T cells. These advances represent an important arena for investigating MS pathogenesis. In this review, we summarize the various approaches taken to engage pathogenic B cells in animal models of MS.
 Autoimmunity Animals B-Lymphocytes - immunology CD4-Positive T-Lymphocytes - immunology Cytokines - metabolism Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Humans Multiple Sclerosis - immunology UIOWA OA Agreement

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