Journal article
Modeling spatial aspects of intracellular dopamine signaling
Methods in molecular biology (Clifton, N.J.), Vol.964, pp.61-75
2013
DOI: 10.1007/978-1-62703-251-3_5
PMCID: PMC4076845
PMID: 23296778
Abstract
Dopamine binding to various dopamine receptors activates multiple
intracellular signaling molecules, some of which interact with calcium activated
signaling pathways. Many experiments measure agonist-stimulated elevations in
signaling molecules using prolonged, diffuse application, whereas the response
of neurons to transient and spatially localized stimuli is more important.
Computational modeling is an approach for investigating the spatial extent, time
course and interaction of post-synaptic signaling molecules activated by
dopamine and other transmembrane receptors. NeuroRD is a simulation algorithm
which can simulate large numbers of pathways and molecules in multiple spines
attached to a dendrite. We explain how to gather the information needed to
develop computational models, to implement such models in NeuroRD, to perform
simulations and to analyze the simulated data from these models.
Details
- Title: Subtitle
- Modeling spatial aspects of intracellular dopamine signaling
- Creators
- Kim Blackwell - George Mason UniversityLane J. Wallace - The Ohio State UniversityBoHung Kim - George Mason UniversityRodrigo Oliveira - George Mason UniversityWonryull Koh - George Mason University
- Resource Type
- Journal article
- Publication Details
- Methods in molecular biology (Clifton, N.J.), Vol.964, pp.61-75
- DOI
- 10.1007/978-1-62703-251-3_5
- PMID
- 23296778
- PMCID
- PMC4076845
- NLM abbreviation
- Methods Mol Biol
- eISBN
- 9781627032513; 1627032517
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Language
- English
- Date published
- 2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446449902771
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