Journal article
Modeling the Effects of Multiple Myeloma on Kidney Function
Scientific reports, Vol.9(1), pp.1726-1726
02/11/2019
DOI: 10.1038/s41598-018-38129-7
PMCID: PMC6370764
PMID: 30741957
Abstract
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved. Specifically, we model the interaction between cells in the proximal tubule of the kidney, free light chains, renal fibroblasts, and myeloma cells. We analyze the model for steady-state solutions to find a mathematically and biologically relevant stable steady-state solution. This foundational model provides a representation of dynamics between key populations in tubulointerstitial fibrosis that demonstrates how these populations interact to affect patient prognosis in patients with MM and renal impairment.
Details
- Title: Subtitle
- Modeling the Effects of Multiple Myeloma on Kidney Function
- Creators
- Julia C Walk - Concordia University WisconsinBruce P Ayati - University of IowaSarah A Holstein - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.9(1), pp.1726-1726
- DOI
- 10.1038/s41598-018-38129-7
- PMID
- 30741957
- PMCID
- PMC6370764
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- NATURE PORTFOLIO
- Number of pages
- 10
- Language
- English
- Date published
- 02/11/2019
- Academic Unit
- Orthopedics and Rehabilitation; Mathematics
- Record Identifier
- 9984240869002771
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