Journal article
Modeling the mechanical consequences of vibratory loading in the vertebral body: microscale effects
Biomechanics and modeling in mechanobiology, Vol.7(3), pp.191-202
05/23/2007
DOI: 10.1007/s10237-007-0085-y
PMID: 17520305
Abstract
Osteoporosis affects nearly 10 million individuals in the United States. Conventional treatments include anti-resorptive drug therapies, but recently, it has been demonstrated that delivering a low magnitude, dynamic stimulus via whole body vibration can have an osteogenic effect without the need for large magnitude strain stimulus. Vibration of the vertebral body induces a range of stimuli that may account for the anabolic response including low magnitude strains, interfacial shear stress due to marrow movement, and blood transport. In order to evaluate the relative importance of these stimuli, we integrated a microstructural model of vertebral cancellous bone with a mixture theory model of the vertebral body. The predicted shear stresses on the surfaces of the trabeculae during vibratory loading are in the range of values considered to be stimulatory and increase with increasing solid volume fraction. Peak volumetric blood flow rates also varied with strain amplitude and frequency, but exhibited little dependence on solid volume fraction. These results suggest that fluid shear stress governs the response of the vertebrae to whole body vibration and that the marrow viscosity is a critical parameter which modulates the shear stress.
Details
- Title: Subtitle
- Modeling the mechanical consequences of vibratory loading in the vertebral body: microscale effects
- Creators
- D. A Dickerson - Purdue University West LafayetteE. A Sander - Purdue University West LafayetteE. A Nauman - Purdue University West Lafayette
- Resource Type
- Journal article
- Publication Details
- Biomechanics and modeling in mechanobiology, Vol.7(3), pp.191-202
- DOI
- 10.1007/s10237-007-0085-y
- PMID
- 17520305
- NLM abbreviation
- Biomech Model Mechanobiol
- ISSN
- 1617-7959
- eISSN
- 1617-7940
- Publisher
- Springer-Verlag
- Language
- English
- Date published
- 05/23/2007
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984197258002771
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