Journal article
Models matter: the search for an effective Staphylococcus aureus vaccine
Nature reviews. Microbiology, Vol.12(8), pp.585-591
08/2014
DOI: 10.1038/nrmicro3308
PMID: 24998740
Abstract
Staphylococcus aureus is a highly successful bacterial pathogen owing to its abundance of cell surface and secreted virulence factors. It is estimated that 30% of the population is colonized with S. aureus, usually on mucosal surfaces, and methicillin-resistant S. aureus is a major public health concern. There have been multiple attempts to develop an S. aureus vaccine using one or more cell surface virulence factors as antigens; all of these vaccine trials have failed. In this Opinion article, we suggest that an over-reliance on rodent models and a focus on targeting cell surface components have been major contributing factors to this failure.
Details
- Title: Subtitle
- Models matter: the search for an effective Staphylococcus aureus vaccine
- Creators
- Wilmara Salgado-Pabón - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USAPatrick M Schlievert - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Microbiology, Vol.12(8), pp.585-591
- Publisher
- England
- DOI
- 10.1038/nrmicro3308
- PMID
- 24998740
- ISSN
- 1740-1534
- eISSN
- 1740-1534
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002397702771
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