Journal article
Models of Muscle Pain: Carrageenan Model and Acidic Saline Model
Current Protocols in Pharmacology, Vol.25(1), pp.5.35.1-5.35.28
06/2004
DOI: 10.1002/0471141755.ph0535s25
PMID: 22294122
Abstract
Carrageenan or acidic saline injected unilaterally into the gastrocnemius muscle or triceps muscle produces a robust and long‐lasting hyperalgesia in rats and mice, which is reversible with systemic administration of opioid or anti‐inflammatory drugs. This unit describes detailed protocols for inducing and measuring hyperalgesia, and provides information on validation of these models. These models are useful for assessing new compounds for their analgesic activity in muscular pain.
Details
- Title: Subtitle
- Models of Muscle Pain: Carrageenan Model and Acidic Saline Model
- Creators
- Rajan Radhakrishnan - University of IowaMarie K Hoeger Bement - University of IowaDavid Skyba - University of IowaKathleen A Sluka - University of IowaLois J Kehl - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Current Protocols in Pharmacology, Vol.25(1), pp.5.35.1-5.35.28
- DOI
- 10.1002/0471141755.ph0535s25
- PMID
- 22294122
- NLM abbreviation
- Curr Protoc Pharmacol
- ISSN
- 1934-8282
- eISSN
- 1934-8290
- Number of pages
- 28
- Language
- English
- Date published
- 06/2004
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040380102771
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