Journal article
Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial
SVOA neurology, Vol.2(1), pp.6-36
2021
PMCID: PMC8815110
PMID: 35128541
Abstract
While it has been shown that aerobic exercise interventions are well tolerated in participants with the Huntington disease (HD) gene mutation, no study to date has tested whether an aerobic exercise intervention benefits brain structure and function in pre-manifest HD.
In this study we utilized magnetic resonance (MR) imaging techniques to assess the efficacy of moderate-to-vigorous exercise treatment relative to active stretching and toning control.
Forty pre-manifest participants with confirmed HD gene expansion were recruited into a two-arm intervention study that included a moderate-to-vigorous intensity home-based walking exercise intervention (N=34) and an active stretching and toning control intervention (N=6). Participants were assessed at baseline and after 26 weeks in one of the two study arms.
25 of the 34 (74%) participants assigned to the moderate-to-vigorous intensity group completed the intervention while 4 of the 6 (67%) participants in the stretching and toning intervention completed the study. The primary analyses compared the two arms of the study and found no statistical differences between the groups. Both groups were found to have improved their cardiorespiratory fitness as assessed by maximal oxygen uptake (VO
max). A secondary analysis combined the two arms of the study and there was a significant relationship (p<0.05) between change in VO
max and change in brain structure.
Though this study did not show efficacy for the exercise intervention, secondary results suggest that aerobic exercise interventions increasing cardiorespiratory fitness may be a potential way to slow progression in pre-manifest HD.
Details
- Title: Subtitle
- Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial
- Creators
- Amro Saad Aldine - Department of Radiology, Ochsner LSU Health Shreveport Academic Medical Center, Shreveport, LA, 71103, USAAmy Ogilvie - Department of Psychiatry, The University of Iowa, Iowa City, IA, 52240, USAJohn Wemmie - Department of Psychiatry, The University of Iowa, Iowa City, IA, 52240, USAJames Kent - Department of Psychology, The University of Texas, Austin, Texas, 78712, USAJordan Schultz - Department of Pharmacy Practice and Science, The University of Iowa, Iowa City, IA, 52240, USAJeffrey D Long - Department of Psychiatry, The University of Iowa, Iowa City, IA, 52240, USAJohn Kamholz - Department of Neurology, The University of Iowa, Iowa City, IA, 52240, USAHassan Sajjad - Department of Internal Medicine, The University of Iowa, Iowa City, IA, 52240, USAJoel Kline - Department of Internal Medicine, The University of Iowa, Iowa City, IA, 52240, USAEmily Shaw - Department of Community and Behavioral Health, The University of Iowa, Iowa City, IA, 52240, USAMichelle Voss - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, 52240, USAJane S Paulsen - Department of Neurology, The University of Wisconsin, Madison, WI, 53705, USAVincent A Magnotta - Department Biomedical Engineering, The University of Iowa, Iowa City, IA, 52240, USA
- Resource Type
- Journal article
- Publication Details
- SVOA neurology, Vol.2(1), pp.6-36
- PMID
- 35128541
- PMCID
- PMC8815110
- eISSN
- 2753-9180
- Language
- English
- Date published
- 2021
- Academic Unit
- Neurology; Psychiatry; Psychological and Brain Sciences; Biostatistics; Pharmacy Practice and Science; Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Epidemiology; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984215124702771
Metrics
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