Modified Endoscopic Ultrasound Needle to Obtain Histological Core Tissue Samples: A Retrospective Analysis

Munish Ashat; Kaartik Soota; Jagpal S Klair; Sarika Gupta; Chris Jensen; Arvind R Murali; Randhir Jesudoss; Rami El-Abiad; Henning Gerke

doi:10.5946/ce.2019.108

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Modified Endoscopic Ultrasound Needle to Obtain Histological Core Tissue Samples: A Retrospective Analysis

Journal article

Open access

Peer reviewed

Modified Endoscopic Ultrasound Needle to Obtain Histological Core Tissue Samples: A Retrospective Analysis

Munish Ashat, Kaartik Soota, Jagpal S Klair, Sarika Gupta, Chris Jensen, Arvind R Murali, Randhir Jesudoss, Rami El-Abiad and Henning Gerke

Clinical endoscopy, Vol.53(4), pp.471-479

07/2020

DOI: 10.5946/ce.2019.108

PMID: 32019294

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Abstract

Background/aims: Endoscopic ultrasound (EUS)-guided fine-needle aspiration is very effective for providing specimens for cytological evaluation. However, the ability to provide sufficient tissue for histological evaluation has been challenging due to the technical limitations of dedicated core biopsy needles. Recently, a modified EUS needle has been introduced to obtain tissue core samples for histological analysis. We aimed to determine (1) its ability to obtain specimens for histological assessment and (2) the diagnostic accuracy of EUS-guided fine-needle biopsy (EUS-FNB) using this needle. Methods: We retrospectively analyzed consecutive cases of FNB using modified EUS needles for 342 lesions in 303 patients. The cytology and histological specimens were analyzed. Diagnostic accuracy was calculated. Results: Adequate cytological and histological assessment was possible in 293/342 (86%) and 264/342 (77%) lesions, respectively. Diagnostic accuracy of the cytological specimen was 294/342 (86%) versus 254/342 (74%) for the histological specimen (p<0.01). Diagnostic accuracy of the combined cytological and histological assessment was 323/342 (94.4%), which was significantly higher than that of both histology alone (p<0.001) and cytology alone (p=0.001). Conclusion: EUS-FNB with the modified EUS needle provided histologic tissue cores in the majority of cases and achieved excellent diagnostic accuracy with few needle passes. Keywords: Diagnostic accuracy; Endoscopic ultrasound; Fine-needle biopsy; Tissue yield.

Diagnostic accuracy

Endoscopic ultrasound

Fine-needle biopsy

Original

Tissue yield

Details

Title: Subtitle: Modified Endoscopic Ultrasound Needle to Obtain Histological Core Tissue Samples: A Retrospective Analysis
Creators: Munish Ashat - University of Iowa Hospitals and Clinics
Kaartik Soota - University of Alabama at Birmingham
Jagpal S Klair - Virginia Mason Medical Center
Sarika Gupta - University of Iowa Hospitals and Clinics
Chris Jensen - University of Iowa Hospitals and Clinics
Arvind R Murali - University of Iowa Hospitals and Clinics
Randhir Jesudoss - University of Iowa Hospitals and Clinics
Rami El-Abiad
Henning Gerke - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Clinical endoscopy, Vol.53(4), pp.471-479
DOI: 10.5946/ce.2019.108
PMID: 32019294
NLM abbreviation: Clin Endosc
ISSN: 2234-2400
eISSN: 2234-2443
Publisher: Korean Society of Gastrointestinal Endoscopy
Language: English
Date published: 07/2020
Academic Unit: Gastroenterology and Hepatology; Pathology; Internal Medicine
Record Identifier: 9984186532102771

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