Journal article
Modulating Ca2+ clearance from neurons
Frontiers in bioscience, Vol.7(1-3), pp.d1255-D1279
05/01/2002
DOI: 10.2741/thayer
PMID: 11991858
Abstract
Neurons are exquisitely sensitive to the duration, amplitude and localization of transient increases in intracellular Ca2+ concentration ([Ca2+]i). Modulation of Ca2+ uptake into the mitochondrion and endoplasmic reticulum, and efflux via the plasma membrane Ca2+ pump and Na+/Ca2+ exchange profoundly affect the shape of [Ca2+]i signals. Ca2+ clearance mechanisms are modulated by other signaling pathways, are sensitive to metabolic state and have a memory of the recent history of cell activation. We present here examples of pharmacologic and endogenous regulation of Ca2+ sequestration and efflux in neurons. Ca2+ clearance mechanisms differentially shape [Ca2+]i signals based on their affinity, capacity and location; their modulation alters specific neuronal functions. The increasingly apparent diversity of the molecular entities that make up the [Ca2+]i regulatory system reveals new sites for modulation. Specialized Ca2+ clearance mechanisms participate in unique cellular functions and thus, are important targets for pharmacological and physiological regulation of the neuron.
Details
- Title: Subtitle
- Modulating Ca2+ clearance from neurons
- Creators
- Stanley A Thayer - Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street, SE, Minneapolis, MN 55455-0217, USAYuriy M UsachevWilliam J Pottorf
- Resource Type
- Journal article
- Publication Details
- Frontiers in bioscience, Vol.7(1-3), pp.d1255-D1279
- DOI
- 10.2741/thayer
- PMID
- 11991858
- NLM abbreviation
- Front Biosci
- ISSN
- 1093-9946
- eISSN
- 1093-4715
- Publisher
- United States
- Grant note
- P50 DA011806 / NIDA NIH HHS
- Language
- English
- Date published
- 05/01/2002
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984072083302771
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