Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Jun Sun; M. Nedim Ince; Clara Abraham; Terrence Barrett; Lisa A. Brenner; Yingzi Cong; Reza Dashti; Pradeep K. Dudeja; David Elliott; Thomas S. Griffith; Peter S. Heeger; Andrew Hoisington; Kaikobad Irani; Tae Kon Kim; Neeraj Kapur; Joseph Leventhal; Mansour Mohamadzadeh; Ece Mutlu; Rodney Newberry; Jonathan U. Peled; Israel Rubinstein; Salyka Sengsayadeth; Chen Sabrina Tan; Xiao-Di Tan; Eric Tkaczyk; Jason Wertheim; Zheng Jenny Zhang

doi:10.1080/19490976.2023.2267180

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Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Journal article

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Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Jun Sun, M. Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David Elliott, Thomas S. Griffith, …

Gut microbes, Vol.15(2), 2267180

12/18/2023

DOI: 10.1080/19490976.2023.2267180

PMCID: PMC10580853

PMID: 37842912

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Abstract

The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.

Details

Title: Subtitle: Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting
Creators: Jun Sun - Jesse Brown VA Medical Center
M. Nedim Ince - Iowa City VA Medical Center
Clara Abraham - Yale University
Terrence Barrett - Lexington VA Health Care System
Lisa A. Brenner - Mental Illness Research, Education and Clinical Centers
Yingzi Cong - The University of Texas Medical Branch at Galveston
Reza Dashti - Stony Brook University
Pradeep K. Dudeja - Jesse Brown VA Medical Center
David Elliott - University of Iowa
Thomas S. Griffith - University of Minnesota
Peter S. Heeger - Cedars-Sinai Medical Center
Andrew Hoisington - Mental Illness Research, Education and Clinical Centers
Kaikobad Irani - University of Iowa
Tae Kon Kim - VA Tennessee Valley Healthcare System
Neeraj Kapur - Lexington VA Health Care System
Joseph Leventhal - Northwestern University
Mansour Mohamadzadeh - The University of Texas Health Science Center at San Antonio
Ece Mutlu - Jesse Brown VA Medical Center
Rodney Newberry - Washington University in St. Louis
Jonathan U. Peled - Memorial Sloan Kettering Cancer Center
Israel Rubinstein - Jesse Brown VA Medical Center
Salyka Sengsayadeth - Making View
Chen Sabrina Tan - University of Iowa
Xiao-Di Tan - Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA, Division of Gastroenterology and Hepatology, Departments of Medicine, Microbiology/Immunology, University of Illinois Chicago, Chicago, IL, USA
Eric Tkaczyk - Lexington VA Health Care System
Jason Wertheim - University of Arizona
Zheng Jenny Zhang - Northwestern University
Resource Type: Journal article
Publication Details: Gut microbes, Vol.15(2), 2267180
DOI: 10.1080/19490976.2023.2267180
PMID: 37842912
PMCID: PMC10580853
ISSN: 1949-0976
eISSN: 1949-0984
Grant note: name: The work was supported by the U.S. Department of Veterans Affairs [VA Field Based Planning Meeting, award: Award (J.S. and M.N.I).
Language: English
Date published: 12/18/2023
Academic Unit: Microbiology and Immunology; Infectious Diseases; Gastroenterology and Hepatology; Iowa Neuroscience Institute; Cardiovascular Medicine; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984479261302771

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