Journal article
Modulation of carotid baroreflex responsiveness in man: effects of posture and propranolol
Journal of applied physiology (1948), Vol.41(3), pp.383-387
09/1976
DOI: 10.1152/jappl.1976.41.3.383
PMID: 965307
Abstract
Carotid baroreceptors were stimulated with graded neck suction in supine and standing volunteers, before and after autonomic blockade, to determine the influence of posture on baroreflex responsiveness. Propranolol significantly augmented baroreflex pulse interval prolongation in the supine position. Upright posture did not modify baroreflex pulse interval responses prior to propranolol, but significantly augmented responses after propranolol. The results suggest that standing enhances baroreflex sensitivity, but that under normal circumstances, this effect is masked by beta-adrenergic stimulation. Augmentation of baroreflex pulse interval prolongation in the supine and standing positions by propranolol may contribute to the effectiveness of this drug in angina pectoris and labile hypertension.
Details
- Title: Subtitle
- Modulation of carotid baroreflex responsiveness in man: effects of posture and propranolol
- Creators
- Dwain L EckbergFrancois M AbboudAllyn L Mark
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1948), Vol.41(3), pp.383-387
- Publisher
- United States
- DOI
- 10.1152/jappl.1976.41.3.383
- PMID
- 965307
- ISSN
- 0021-8987
- eISSN
- 2691-2473
- Language
- English
- Date published
- 09/1976
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025475702771
Metrics
26 Record Views