Journal article
Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials
Device, Vol.2(5), 100320
05/17/2024
DOI: 10.1016/j.device.2024.100320
PMCID: PMC11192243
PMID: 38911126
Abstract
Diabetic wound healing is uniquely challenging to manage due to chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, is also known to provide unique therapeutic immune-modulating effects. To facilitate delivery of CO, we have designed hyaluronic-acid-based CO gas-entrapping materials (CO-GEMs) for topical and prolonged gas delivery to the wound bed. We demonstrate that CO-GEMs promote the healing response in murine diabetic wound models (full-thickness wounds and pressure ulcers) compared to N2-GEMs and untreated controls.
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•Topical delivery of CO is feasible using gas-entrapping materials•Topical delivery of CO resulted in high local and low systemic levels of CO•CO gas-entrapping materials can improve wound healing in diabetic mouse models
Wound healing presents a unique challenge for patients with diabetes. Gas therapies have gained significant attention in the wound-healing community. Carbon monoxide (CO) is a small molecule that is well known for its immune-modulating properties when administered at sublethal concentrations. CO is currently in clinical trials for lung disease, sickle cell anemia, and organ transplantation. Here, we investigated the effects of CO in an in vitro wound-healing model and subsequently developed and tested CO gas-entrapping materials (CO-GEMs) for topical application on wounds to promote healing. In this study, we report the efficacy of CO-GEMs in treating full-thickness wounds and pressure ulcers in diabetic mouse models. Collectively, our findings demonstrate that these novel gas entrapping materials could serve as an alternative therapy to both protect the wound bed and promote healing and replace bulky hyperbaric chambers, standard gauze wound dressings, or expensive skin grafts.
Nonhealing diabetic wounds are common in patients with diabetes. Our study utilized FDA-approved gas-entrapping materials for controlled carbon monoxide release. This technique improved dermal fibroblast function, reduced proinflammatory cytokines, and accelerated wound closure in mice, indicating the potential for gas-entrapping materials to enhance diabetic wound healing without drugs.
Details
- Title: Subtitle
- Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials
- Creators
- Emily Witt - University of Iowa, Radiation OncologyAlexander J. Leach - University of IowaJianling Bi - University of Iowa, Radiation OncologySamual Hatfield - University of IowaAlicia T. Cotoia - University of North Carolina WilmingtonMegan K. McGovern - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USAArielle B. Cafi - University of IowaAshley C. Rhodes - University of IowaAustin N. Cook - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USASlyn Uaroon - University of IowaBishal Parajuli - University of Iowa, PathologyJinhee Kim - University of TorontoVivian Feig - Brigham and Women's HospitalAlexandra Scheiflinger - Beth Israel Deaconess Medical CenterIkenna Nwosu - University of IowaMiguel Jimenez - Massachusetts Institute of TechnologyMitchell C. Coleman - University of Iowa, Radiation OncologyMarisa R. Buchakjian - University of Iowa, OtolaryngologyDustin E. Bosch - University of Iowa, PathologyMichael S. Tift - University of North Carolina WilmingtonGiovanni Traverso - Massachusetts Institute of TechnologyLeo E. Otterbein - Beth Israel Deaconess Medical CenterJames D. Byrne - University of Iowa, Radiation Oncology
- Resource Type
- Journal article
- Publication Details
- Device, Vol.2(5), 100320
- Publisher
- Elsevier Inc; CAMBRIDGE
- DOI
- 10.1016/j.device.2024.100320
- PMID
- 38911126
- PMCID
- PMC11192243
- ISSN
- 2666-9986
- eISSN
- 2666-9986
- Grant note
- DOI: 10.13039/100000005, name: US Department of Defense; DOI: 10.13039/100000048, name: American Cancer Society; DOI: 10.13039/100000892, name: Prostate Cancer Foundation; DOI: 10.13039/100006919, name: Massachusetts Institute of Technology; DOI: 10.13039/100000001, name: National Science Foundation; DOI: 10.13039/100000002, name: National Institutes of Health
- Language
- English
- Electronic publication date
- 03/12/2024
- Date published
- 05/17/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pathology; Orthopedics and Rehabilitation; Radiation Oncology; Otolaryngology
- Record Identifier
- 9984581052702771
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