Journal article
Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A
Developmental biology, Vol.182(1), pp.114-120
02/01/1997
DOI: 10.1006/dbio.1996.8463
PMID: 9073455
Abstract
Wnt genes encode secreted proteins which are implicated in receptor-mediated cell-cell signaling events important in embryogenesis, but the second messenger systems modulated by Wnts have not been identified. We report that ectopic expression of Xwnt-5A in zebrafish embryos enhances the frequency of intracellular Ca2+ transients in the enveloping layer of the blastodisc, whereas Xwnt-8 does not. These transients are independent of extracellular Ca2+. Consistent with the observed Ca2+ transients playing a role in responses of embryos to Xwnt-5A, we report that the ligand-activated serotonin type 1C receptor, which stimulates PI cycle activity and Ca2+ signaling independent of Wnts, phenocopies embryonic responses to Xwnt-5A. These results suggest that intercellular signaling by a subset of vertebrate Wnts involves modulation of a intracellular Ca2+ signaling pathway, which may arise from phosphatidylinositol cycle activity.
Details
- Title: Subtitle
- Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A
- Creators
- D C Slusarski - Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195, USAJ Yang-SnyderW B BusaR T Moon
- Resource Type
- Journal article
- Publication Details
- Developmental biology, Vol.182(1), pp.114-120
- DOI
- 10.1006/dbio.1996.8463
- PMID
- 9073455
- NLM abbreviation
- Dev Biol
- ISSN
- 0012-1606
- eISSN
- 1095-564X
- Publisher
- United States
- Grant note
- F32 GM17484 / NIGMS NIH HHS
- Language
- English
- Date published
- 02/01/1997
- Academic Unit
- Iowa Neuroscience Institute; Biology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983991989802771
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