Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications

Shoma Sato; Toshihiro Kitamoto; Takaomi Sakai

doi:10.3389/fnbeh.2014.00400

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Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications

Journal article

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Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications

Shoma Sato, Toshihiro Kitamoto and Takaomi Sakai

Frontiers in behavioral neuroscience, Vol.8, pp.400-400

12/02/2014

DOI: 10.3389/fnbeh.2014.00400

PMID: 25520634

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Abstract

Transient receptor potential (TRP) channels have attracted considerable attention because of their vital roles in primary sensory neurons, mediating responses to a wide variety of external environmental stimuli. However, much less is known about how TRP channels in the brain respond to intrinsic signals and are involved in neurophysiological processes that control complex behaviors. Painless (Pain) is the Drosophila TRP channel that was initially identified as a molecular sensor responsible for detecting noxious thermal and mechanical stimuli. Here, we review recent behavioral genetic studies demonstrating that Pain expressed in the brain plays a critical role in both innate and learned aspects of sexual behaviors. Several members of the TRP channel superfamily play evolutionarily conserved roles in sensory neurons as well as in other peripheral tissues. It is thus expected that brain TRP channels in vertebrates and invertebrates would have some common physiological functions. Studies of Pain in the Drosophila brain using a unique combination of genetics and physiological techniques should provide valuable insights into the fundamental principles concerning TRP channels expressed in the vertebrate and invertebrate brains.

sexual receptivity

Neuroscience

courtship

learning and memory

Drosophila

sexual orientation

Painless

TRP channels

Details

Title: Subtitle: Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications
Creators: Shoma Sato - Department of Biological Sciences, Tokyo Metropolitan University
Toshihiro Kitamoto - Department of Anesthesia and Pharmacology, University of Iowa
Takaomi Sakai - Department of Biological Sciences, Tokyo Metropolitan University
Resource Type: Journal article
Publication Details: Frontiers in behavioral neuroscience, Vol.8, pp.400-400
DOI: 10.3389/fnbeh.2014.00400
PMID: 25520634
NLM abbreviation: Front Behav Neurosci
ISSN: 1662-5153
eISSN: 1662-5153
Publisher: Frontiers Media S.A
Language: English
Date published: 12/02/2014
Academic Unit: Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
Record Identifier: 9984006479402771

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