Journal article
Modulation of mitomycin C-induced genotoxicity by acetyl- and thio- analogues of salicylic acid
In vivo (Athens), Vol.23(2), pp.303-307
03/01/2009
PMID: 19414419
Abstract
BACKGROUNDRecent reports regarding acetylsalicylic acid (ASA) and its metabolites suggest suppressive effects against mitomycin C (MMC)-induced genotoxicity in a mice chromosomal aberration assay. Keeping this in mind, the potential anti-genotoxic effect of the thio-analogue of salicylic acid namely thio-salicylic acid (TSA) was speculated upon. The present study investigated and compared the anti-genotoxic potential of ASA and TSA.MATERIALS AND METHODSThe study was performed in male swiss mice (20+/-2 g) using single-cell gel electrophoresis and a peripheral blood micronucleus assay. ASA and TSA (5, 10 or 20 mg/kg) were administered 15 minutes after MMC (1 mg/kg) once daily for 3 or 7 days.RESULTSBoth ASA and TSA significantly decreased the DNA damage induced by MMC as indicated by a decrease in the comet parameters in bone marrow cells and decreased frequencies of micronucleated reticulocytes in peripheral blood.CONCLUSIONThe results clearly demonstrate the anti-genotoxic potential of ASA and TSA.
Details
- Title: Subtitle
- Modulation of mitomycin C-induced genotoxicity by acetyl- and thio- analogues of salicylic acid
- Creators
- Amol Ashok PawarAjit VikramDurga Nand TripathiShweta PadmanabhanPoduri RamaraoGopabandhu Jena
- Resource Type
- Journal article
- Publication Details
- In vivo (Athens), Vol.23(2), pp.303-307
- PMID
- 19414419
- ISSN
- 0258-851X
- eISSN
- 1791-7549
- Language
- English
- Date published
- 03/01/2009
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984359933802771
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