Journal article
Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl- l-aspartate in murine colon carcinoma no. 26
European journal of cancer (1990), Vol.31(6), pp.974-976
1995
DOI: 10.1016/0959-8049(95)00191-3
PMID: 7646931
Abstract
Modulation of the therapeutic efficacy of cisplatin (CDDP) and 5-fluoro-2'-deoxyuridine (FdUrd) alone and in combination with
N-phosphonacetyl-
l-aspartate (PALA) was evaluated in mice bearing colon carcinoma (C-26) using a weekly intravenous (i.v.) push schedule for 3 weeks. A non-toxic dose of PALA (100 mg/kg) was administered i.v. 24 h prior to the i.v. administration of CDDP ± FdUrd. The maximum tolerated doses (MTD) of CDDP and FdUrd when used as a single agent were 9 and 400 mg/kg, respectively. In combination, however, the MTD of CDDP and FdUrd were 2.5 and 300 mg/kg, respectively. PALA did not significantly affect the MTD. PALA improved the antitumour activity of CDDP or FdUrd when used alone; however, the highest tumour response, 66% complete tumour regression, was achieved with a PALA modulation of CDDP and FdUrd in combination.
Details
- Title: Subtitle
- Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl- l-aspartate in murine colon carcinoma no. 26
- Creators
- J.A.M. Van Laar - Roswell Park Cancer InstituteE.G. Mayhew - Princeton UniversityS. Cao - Roswell Park Cancer InstituteF.A. Durrani - Roswell Park Cancer InstituteG.J. Peters - University of AmsterdamY.M. Rustum - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- European journal of cancer (1990), Vol.31(6), pp.974-976
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0959-8049(95)00191-3
- PMID
- 7646931
- ISSN
- 0959-8049
- eISSN
- 1879-0852
- Language
- English
- Date published
- 1995
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359830602771
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