Journal article
Modulation of the cardiovascular system by leptin
Biochimie, Vol.94(10), pp.2097-2103
10/2012
DOI: 10.1016/j.biochi.2012.03.019
PMID: 22490727
Abstract
It is well established that individuals with the metabolic syndrome have a significantly increased risk of cardiovascular disease and much effort has been expended to elicit the underlying mechanisms. Various studies have proposed that excessive or deficient physiological effects mediated by leptin make an important contribution, yet many paradoxical observations often preclude a clear definition of the role of leptin. This review article will briefly discuss principal and most recent evidence on direct and indirect regulation of the cardiovascular system by leptin, focusing on cardiac structural and functional as well as vascular effects.
Details
- Title: Subtitle
- Modulation of the cardiovascular system by leptin
- Creators
- E Dale Abel - Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USAGary Sweeney
- Resource Type
- Journal article
- Publication Details
- Biochimie, Vol.94(10), pp.2097-2103
- Publisher
- France
- DOI
- 10.1016/j.biochi.2012.03.019
- PMID
- 22490727
- ISSN
- 0300-9084
- eISSN
- 1638-6183
- Grant note
- U01-HL-70525 / NHLBI NIH HHS Canadian Institutes of Health Research R01-HL-73167 / NHLBI NIH HHS U01-HL-087947 / NHLBI NIH HHS
- Language
- English
- Date published
- 10/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024558902771
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