Journal article
Modulation of the host immune response by respiratory syncytial virus proteins
Journal of microbiology (Seoul, Korea), Vol.55(3), pp.161-171
03/2017
DOI: 10.1007/s12275-017-7045-8
PMID: 28243940
Abstract
Respiratory syncytial virus (RSV) causes severe respiratory disease in both the very young and the elderly. Nearly all individuals become infected in early childhood, and reinfections with the virus are common throughout life. Despite its clinical impact, there remains no licensed RSV vaccine. RSV infection in the respiratory tract induces an inflammatory response by the host to facilitate efficient clearance of the virus. However, the host immune response also contributes to the respiratory disease observed following an RSV infection. RSV has evolved several mechanisms to evade the host immune response and promote virus replication through interactions between RSV proteins and immune components. In contrast, some RSV proteins also play critical roles in activating, rather than suppressing, host immunity. In this review, we discuss the interactions between individual RSV proteins and host factors that modulate the immune response and the implications of these interactions for the course of an RSV infection.
Details
- Title: Subtitle
- Modulation of the host immune response by respiratory syncytial virus proteins
- Creators
- Megan E Schmidt - University of Iowa, Microbiology and ImmunologySteven M Varga - University of Iowa, Microbiology and Immunology
- Resource Type
- Journal article
- Publication Details
- Journal of microbiology (Seoul, Korea), Vol.55(3), pp.161-171
- Publisher
- Korea (South)
- DOI
- 10.1007/s12275-017-7045-8
- PMID
- 28243940
- ISSN
- 1225-8873
- eISSN
- 1976-3794
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology; Community and Behavioral Health
- Record Identifier
- 9983769580902771
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