Journal article
Modulatory action of cholinergic drugs on N-methyl-D-aspartate response in dissociated rat nucleus basalis of Meynert neurons
Neuroscience letters, Vol.130(2), pp.243-247
1991
DOI: 10.1016/0304-3940(91)90406-J
PMID: 1839057
Abstract
The effect of cholinergic drugs on N-methyl-D-aspartate (NMDA)-activated responses in neurons dissociated freshly from the nucleus basalis of Meynert (nBM) of immature and mature rats were investigated with the whole-cell patch-clamp technique. The NMDA (10(-4) M)-evoked inward current (INMDA) consisted of transient peak and successive steady-state components. In mature neurons, the peak component was suppressed by pretreatment with acetylcholine (ACh, 10(-12)-10(-5) M) but facilitated by higher concentrations (greater than 10(-5) M). Regardless of the concentration, ACh had no effect on INMDA of immature neurons. The results suggest that ACh behaves as either inhibitory or excitatory modulator of glutaminergic transmission in nBM neurons of adult mammals depending on ACh concentration.
Details
- Title: Subtitle
- Modulatory action of cholinergic drugs on N-methyl-D-aspartate response in dissociated rat nucleus basalis of Meynert neurons
- Creators
- N AKAIKE - Tohoku univ. school medicine, dep. neurophysiology, Sendai 980, JapanN HARATA - Tohoku univ. school medicine, dep. neurophysiology, Sendai 980, JapanN TATEISHI - Tohoku univ. school medicine, dep. neurophysiology, Sendai 980, Japan
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.130(2), pp.243-247
- Publisher
- Elsevier; Shannon
- DOI
- 10.1016/0304-3940(91)90406-J
- PMID
- 1839057
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Grant note
- DOI: 10.13039/501100001700, name: Ministry of Education, Culture, Sports, Science and Technology
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025694602771
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