Molecular Characterization of the β-Lactamases from Clinical Isolates of Moraxella (Branhamella) catarrhalis Obtained from 24 U.S. Medical Centers during 1994–1995 and 1997–1998

Sandra S Richter; Patricia L Winokur; Angela B Brueggemann; Holly K Huynh; Paul R Rhomberg; Elizabeth M Wingert; Gary V Doern

doi:10.1128/AAC.44.2.444-446.2000

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Molecular Characterization of the β-Lactamases from Clinical Isolates of Moraxella (Branhamella) catarrhalis Obtained from 24 U.S. Medical Centers during 1994–1995 and 1997–1998

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Molecular Characterization of the β-Lactamases from Clinical Isolates of Moraxella (Branhamella) catarrhalis Obtained from 24 U.S. Medical Centers during 1994–1995 and 1997–1998

Sandra S Richter, Patricia L Winokur, Angela B Brueggemann, Holly K Huynh, Paul R Rhomberg, Elizabeth M Wingert and Gary V Doern

Antimicrobial agents and chemotherapy, Vol.44(2), pp.444-446

Note

02/2000

DOI: 10.1128/AAC.44.2.444-446.2000

PMCID: PMC89702

PMID: 10639381

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Abstract

The β-lactamases from 403 Moraxella ( Branhamella ) catarrhalis clinical isolates obtained during 1994–1995 and 1997–1998 U.S. multicenter surveillance studies were characterized by isoelectric focusing. The overall prevalences of the BRO-1 and BRO-2 enzymes among β-lactamase-positive isolates were estimated to be 97.5 and 2.5%, respectively. The minimum inhibitory concentrations (MICs) of ampicillin for all BRO-2-producing isolates were ≤1 μg/ml; however, numerous β-lactamase-positive isolates for which the ampicillin MICs were ≤1 μg/ml produced the BRO-1 enzyme (88.1%).

Mechanisms of Resistance

Details

Title: Subtitle: Molecular Characterization of the β-Lactamases from Clinical Isolates of Moraxella (Branhamella) catarrhalis Obtained from 24 U.S. Medical Centers during 1994–1995 and 1997–1998
Creators: Sandra S Richter - Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Patricia L Winokur - Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Angela B Brueggemann - Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Holly K Huynh - Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Paul R Rhomberg - Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Elizabeth M Wingert - Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Gary V Doern - Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.44(2), pp.444-446
Series: Note
DOI: 10.1128/AAC.44.2.444-446.2000
PMID: 10639381
PMCID: PMC89702
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Publisher: American Society for Microbiology
Language: English
Date published: 02/2000
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Medicine Administration; Internal Medicine
Record Identifier: 9984094630302771

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